Blood inflammatory patterns in different respiratory phenotypes from the general population
P. Girardi, M. Ferrari, C. Bombieri, V. Locascio, M. Olivieri, L. Perbellini, M. Nicolis, S. Sembeni, G. Verlato, Z. Maria Elisabetta, R. de Marco (Verona, Italy)
Source: Annual Congress 2010 - COPD: treatment and monitoring
Session: COPD: treatment and monitoring
Session type: Thematic Poster Session
Number: 1334
Disease area: Airway diseases
Abstract Background Few studies have considered the distribution of the granulocytes in the blood of different respiratory phenotypes. Aims The relationship between the pattern of inflammatory cells in the blood and the phenotypes of asthma, rhinitis and chronic respiratory symptoms. Methods The peripheral blood eosinophil (EO), neutrophil (NE) and basophil (BA) count was measured in a sample of cases (allergic (146) and non allergic rhinitis (62), past (104) and current asthma (181), COPD (25), other chronic respiratory diagnosis (81)) and controls (185), identified in the ongoing GEIRD study (Verona, Italy). Cases and controls were diagnosed during a clinical examination that included a detailed interview, pre/post bronchodilator spirometry, methacoline challenge, skin prick tests. The average difference in cell count with respect to controls, adjusted for confounders, was estimated in each phenotype. Results In the general population (see figure), all subjects with respiratory diseases (except non allergic rhinitis and COPD) showed a statistically significant higher EO and BA count with respect to controls with a wide variation among phenotypes. NE count showed a relevant increase only in COPD. Adjusted percentage variation of the granulocyte count with respect to controls.
Conclusions The granulocyte count in the blood may help to improve the identification of respiratory phenotypes in epidemiologic studies of respiratory diseases.
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P. Girardi, M. Ferrari, C. Bombieri, V. Locascio, M. Olivieri, L. Perbellini, M. Nicolis, S. Sembeni, G. Verlato, Z. Maria Elisabetta, R. de Marco (Verona, Italy). Blood inflammatory patterns in different respiratory phenotypes from the general population. Eur Respir J 2010; 36: Suppl. 54, 1334
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