Source: Annual Congress 2010 - New treatments for asthma and COPD
Disease area: Airway diseases

Abstract

Background:Retrospective studies have shown that treatment with statins is associated with improved survival after COPD exacerbations (ECOPD).
Objectives:To evaluate prospectively the role of statins on the outcomes of patients hospitalized for ECOPD.
Methods:We studied prospectively 245 patients admitted to hospital for ECOPD. Patients‘ characteristics, COPD severity, treatment and health-related quality of life (HRQoL) were recorded. Patients were evaluated monthly for one year recording new ECOPD, and survival HRQoL was recorded at the time of hospital discharge, and two, six and twelve months later. Patients whose statin therapy was interrupted for any reason were excluded from the study. Decisions for treatment and discharge were made by attending physicians not involved in this study. The role of statins on outcomes was evaluated by Cox regression analysis after proper adjustments.
Results:Patients receiving statins as outpatients prior to their admission had better survival from ECOPD compared to patients not receiving statins (p<0.001). The use of statins for one year after hospital discharge did not improve survival (p=0.681), but patients on statins had less ECOPD in one year compared to patients not receiving statins (2.1±2.7 vs. 2.8± 3.2 respectively, p=0.037). Moreover, the use of statins prolonged time to next ECOPD and next severe ECOPD (p<0.001 and p=0.015 respectively). Finally, the use of statins was related to a better improvement in HRQoL at 2, 6 and 12 months after discharge (p<0.001).
Conclusions:The use of statins does not affect one-year survival after ECOPD, but is related to a smaller number of ECOPD and prolonged time to next ECOPD, as well as better improvement in HRQoL.

Rating:

Share or cite this content

Citations should be made in the following way:
K. Bartziokas, A. Papaioannou, M. Minas, A. Haniotou, K. Gourgoulianis, K. Kostikas (Larissa, Athens, Greece). Statins and outcome of COPD patients after hospitalization for COPD exacerbations. Eur Respir J 2010; 36: Suppl. 54, 1162

Member's Comments

No comment yet.

Related content which might interest you: Cardiovascular medications and mortality in patients hospitalised with acute exacerbations of COPD Source: Annual Congress 2013 –COPD biomarkers Year: 2013 β-blockers and risk of COPD exacerbation requiring hospitalisation in patients with COPD Source: Annual Congress 2011 - Biomarkers and exacerbations of asthma and COPD Year: 2011 Rehospitalizations for an acute exacerbation among patients with COPD Source: International Congress 2015 – Clinical assessment and monitoring of asthma and COPD Year: 2015 Predictors of exacerbations of COPD Source: Eur Respir J 2005; 26: Suppl. 49, 284s Year: 2005 Characterization of readmissions in patients hospitalized with COPD exacerbation Source: International Congress 2016 – Novel avenues in the treatment of COPD II Year: 2016 COPD mortality after severe exacerbations Source: Virtual Congress 2020 – Monitoring of patients with COPD Year: 2020 The impact of comorbidities on the short-term serious health outcomes in hospitalized COPD patients due to exacerbation Source: Annual Congress 2013 –COPD treatment and others Year: 2013 Predictors of exacerbations requiring hospitalisation in patients with stable COPD Source: Eur Respir J 2006; 28: Suppl. 50, 177s Year: 2006 Predictors of readmission after hospitalization for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) Source: Annual Congress 2013 –COPD: markers and inflammation Year: 2013 Predictors of mortality in COPD patients after hospitalization due to an exacerbation Source: International Congress 2019 – Exacerbations of airway diseases Year: 2019 Risk factors for another hospitalization in COPD patients hospitalized for exacerbation Source: International Congress 2016 – Hospitalisation and comorbidities in chronic lung diseases Year: 2016 The impact of bronchiectasis on outcomes in a large cohort of patients hospitalised with exacerbations of COPD Source: Annual Congress 2013 –Treating bronchiectasis in respiratory patients Year: 2013 Key factors associated with readmission in COPD patients Source: Annual Congress 2013 –COPD biomarkers Year: 2013 Efficacy of roflumilast with concomitant cardiovascular medication in patients with COPD Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management Year: 2013 Sit-to-stand ability in patients hospitalised for acute exacerbation of COPD: Clinical characteristics and short-term outcomes Source: International Congress 2015 – New insights into exercise and muscle performance Year: 2015 Prognosis after hospitalization for acute exacerbations of COPD Source: Eur Respir J 2001; 18: Suppl. 33, 209s Year: 2001 Early re-admissions after severe COPD exacerbations Source: Eur Respir J 2003; 22: Suppl. 45, 511s Year: 2003 The relation of comorbidities with the exacerbation severity in patients with COPD Source: Annual Congress 2013 –COPD mechanisms Year: 2013 COPD patients admitted in ICU for acute exacerbation: Impact of exacerbation factors on prognosis Source: International Congress 2016 – Dealing with the complexity of critically-ill patients Year: 2016 COPD patients with asthma, characteristics and risk of exacerbations Source: International Congress 2019 – Multimorbidity in airway diseases and appropriate inhaled corticosteroid use in COPD Year: 2019