Efficacy of UR-63325, a new H4 receptor antagonist, in two rodent asthma models

S. Sánchez-Gómez, J. Alfón, N. Ardanaz, B. Gil-Torregrosa, A. Fernández, E. Carceller, L. Gómez, D. Balsa, X. Bartrolí, M. Merlos (Palau-solità i Plegamans, Spain)

Source: Annual Congress 2010 - Models of airways disease
Session: Models of airways disease
Session type: E-Communication Session
Number: 3707
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Sánchez-Gómez, J. Alfón, N. Ardanaz, B. Gil-Torregrosa, A. Fernández, E. Carceller, L. Gómez, D. Balsa, X. Bartrolí, M. Merlos (Palau-solità i Plegamans, Spain). Efficacy of UR-63325, a new H4 receptor antagonist, in two rodent asthma models. Eur Respir J 2010; 36: Suppl. 54, 3707

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Mas receptor antagonist inhibits the pro-resolutive effects of Angiotensin-(1-7) in an experimental model of asthma.
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

CS-003, a novel triple neurokinin receptor antagonist, inhibits symptoms of respiratory diseases models in guinea pigs
Source: Eur Respir J 2006; 28: Suppl. 50, 664s
Year: 2006

A novel dual-agonist challenge model in guinea pigs for assessment of individual and combined muscarinics antagonists and b2 adrenoceptor agonists bronchodilator efficacy
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011

Pharmacological profile of a novel, potent and oral TRPA1 antagonist. Characterization in a preclinical model of induced cough
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

Efficacy of a novel PI3Kd inhibitor, DS-1515 in animal models of asthma
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018




A novel lung pharmacokinetic model predicts lung exposure and supports dose selection for clinical study of AZD2115, a dual muscarinic receptor antagonist/beta2 adrenoceptor agonist (MABA)
Source: International Congress 2015 – Notable abstracts in exacerbations, mechanisms and biomarkers in COPD
Year: 2015


Alpha-7 nicotinic receptor stimulation reduces airway inflammation in a murine model of asthma
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Metabolism of ASM-024, a novel nicotinic agonist being developed for the treatment of asthma
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

The in vitro profile of ADC3680, a potent and selective CRTh2 antagonist for the treatment of inadequately controlled asthma
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

A dual-acting muscarinic antagonist, ß2-agonist [MABA] molecule (GSK961081) improves lung function in COPD. A randomised trial
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Efficacy of sitaxsentan, an endothelin-A receptor antagonist in PAH in traditional vs. expanded study populations
Source: Eur Respir J 2004; 24: Suppl. 48, 109s
Year: 2004

Selective versus non-selective endothelin receptor antagonists
Source: Annual Congress 2005 - New treatments in pulmonary hypertension
Year: 2005

Anti-asthmatic effects of losartan, a blocker of angiotensin II type 1 receptor, in a rat model of allergic asthma
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009

Nicotinic alpha-7 receptor stimulation (a7nAChR) inhibited NF-kB/STAT3/SOCS3 pathways in a murine model of asthma.
Source: International Congress 2017 – Novel mechanisms and treatments for asthma
Year: 2017



Pharmacological treatment of asthma today
Source: Eur Respir J 2001; 18: 34S-40S
Year: 2001



The novel dual D2 dopamine receptor, β2-adrenoceptor agonist, Viozan™ (AR-C68397AA) improves quality of life and perception of efficacy
Source: Eur Respir J 2001; 18: Suppl. 33, 3s
Year: 2001

A phase I inhalation study on ASM-024, a novel nicotinic agonist being developed for the treatment of asthma
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Effect of AVE5883, a dual NK1/NK2 receptor antagonist, on airway responsiveness to neurokinin A in asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

The novel dual D2 dopamine receptor, β2-adrenoceptor agonist Viozan™ (AR-C68397AA) is well tolerated in a dog model
Source: Eur Respir J 2001; 18: Suppl. 33, 406s
Year: 2001

Protective effect of a protein epitope mimetic (PEM) CCR10 antagonist, POL7085, in an allergic model of asthma
Source: Annual Congress 2011 - Translational models of airway disease
Year: 2011