Source: Annual Congress 2010 - Nocturnal cardiology: chronic heart failure, acute chest syndrome, coronary artery disease and collagen vascular disease
Disease area: Pulmonary vascular diseases, Sleep and breathing disorders

Abstract

Background: Obstructive sleep apnea (OSA) is known as a major cardiovascular risk factor and is diagnosed in a majority of patients with aortic dissection. Previous data suggested that OSA accelerates aortic expansion but the mechanisms for the association have not been explored. Objective: To assess the relationship between OSA, its vascular consequences and aortic root size. Patients and Methods: 156 newly diagnosed OSA patients free of cardiovascular disease and medication were included (136 men, Age: 49 ±10yrs, BMI: 27 ±3kg/m2, AHI: 42 ±18/h, clinical systolic/diastolic blood pressure (BP): 132 ±16/87 ±10 mmHg). Patients underwent Doppler echocardiography for measuring aortic root diameter, polysomnography, clinical BP measurements and 24-h ambulatory BP monitoring (ABPM), baroreflex sensitivity (BRS) and carotid-to-femoral pulse wave velocity (PWV). Results: Severity of OSA as defined by quartiles of mean nocturnal Sa02 (≤92.1%, 92.2%-93.3%, 93.4%-94.7%, >94.7%) was significantly associated with a greater aortic root diameter adjusted for height (p=0.008). In univariate analysis, greater aortic root size was also associated with older age (p=0.0002), higher diastolic BP [clinical (p=0.0004); ABPM (p= 0.01)] and PWV (p= 0.02). A lower mean nocturnal SaO2 was linked with BRS (p=0.0008), thus influencing BP values and PWV. In multivariate stepwise regression, diastolic BP and age were the only significant determinants for aortic root size. Conclusion: Severity of OSA-related nocturnal hypoxia decreases BRS. This in turn increases diastolic BP levels which is one of the main factors influencing aortic root size in OSA.

Rating:

Share or cite this content

Citations should be made in the following way:
J. P. Baguet, C. Minville, R. Tamisier, G. Barone-Rochette, O. Ormezzano, P. Levy, J. L. Pepin (Grenoble Cedex 09, La Tronche, France). The association between obstructive sleep apnea and greater aortic size can be explained by the amount of oxygen desaturation and diastolic blood pressure. Eur Respir J 2010; 36: Suppl. 54, 913

Member's Comments

No comment yet.

Related content which might interest you: Left ventricular diastolic dysfunction is associated with severity of oxygen desaturation in obstructive sleep apnea (OSA) Source: Annual Congress 2009 - Cardiovascular complications in obstructive sleep apnoea Year: 2009 Management of hypertension in obstructive sleep apnoea: predicting blood pressure reduction under continuous positive airway pressure Source: Eur Respir J, 50 (4) 1701822; 10.1183/13993003.01822-2017 Year: 2017 Blood pressure responsiveness to obstructive events during sleep after chronic CPAP Source: Eur Respir J 2003; 21: 509-514 Year: 2003 Influence of continuous positive airway pressure therapy on endothelial function and blood pressure in patients with arterial hypertension and obstructive sleep apnoea syndrome Source: Eur Respir J 2006; 28: Suppl. 50, 814s Year: 2006 The relationship between hypoxemia and ambulatory blood pressure in obstructive sleep apnea-hypopnea syndrome Source: Eur Respir J 2007; 30: Suppl. 51, 592s Year: 2007 Correlations between severity of obstructive sleep apnoea and systolic pulmonary artery pressure: preliminary results Source: International Congress 2018 – Cardiovascular and metabolic consequences of sleep-disordered breathing Year: 2018 Baroreflex control of heart rate during sleep in severe obstructive sleep apnoea: effects of acute CPAP Source: Eur Respir J 2006; 27: 128-135 Year: 2006 Obstructive sleep apnea syndrome and left ventricular diastolic function: effects of nasal continuous positive airway pressure (CPAP) Source: Annual Congress 2006 - Therapeutic effects in obstructive sleep apnoea Year: 2006 Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients Source: Eur Respir J 2006; 27: 1229-1235 Year: 2006 Sex differences in the association between arterial hypertension, blood pressure and sleep apnea in the general population Source: Sleep and Breathing Conference 2021 Year: 2021 Importance of controlled blood pressure values in a population with obstructive sleep apnea syndrome (OSA) and arterial hypertension (HT) Source: Annual Congress 2011 - Cardiometabolic and neurocognitive changes in obstructive sleep apnoea Year: 2011 Comparison of peripheral arterial tonometry and invasive blood pressure in patients with obstructive sleep apnoea Source: Eur Respir J 2001; 18: Suppl. 33, 519s Year: 2001 Daytime measurements underestimate nocturnal oxygen desaturations in pulmonary arterial and chronic thromboembolic pulmonary hypertension Source: Annual Congress 2012 - Pulmonary circulation: acute and chronic pulmonary embolism Year: 2012 Effects of CPAP on blood pressures and left ventricular structure in male patients with obstructive sleep apnea Source: Eur Respir J 2006; 28: Suppl. 50, 816s Year: 2006 Impact of obstructive sleep apnea on diastolic function Source: Annual Congress 2011 - Obstructive sleep apnoea: the heart and the brain Year: 2011 CPAP and measures of cardiovascular risk in males with OSAS Source: Eur Respir J 2008; 32: 1488-1496 Year: 2008 Impact of obstructive sleep apneas/hypopneas on blood pressure during a short period of stable sleep. A relevance for blood pressure variation? Source: Annual Congress 2011 - Cardiometabolic and neurocognitive changes in obstructive sleep apnoea Year: 2011 Cerebral oxygenation monitoring during obstructive sleep apnoea reflects changes in cerebral blood flow velocity as well as arterial oxygen saturation changes Source: Eur Respir J 2002; 20: Suppl. 38, 295s Year: 2002 Cardiac diastolic function and hypercapnic ventilatory responses in central sleep apnoea Source: Eur Respir J 2002; 20: 717-723 Year: 2002 Automated office blood pressure measurement increases prevalence of masked hypertension in patients with obstructive sleep apnoea Source: Virtual Congress 2020 – Consequences for obstructive sleep apnoea and potential modalities for early identification Year: 2020