Source: Annual Congress 2010 - Nocturnal cardiology: chronic heart failure, acute chest syndrome, coronary artery disease and collagen vascular disease
Disease area: Sleep and breathing disorders

Abstract

Introduction. Few studies have evaluated the submaximal aerobic capacity of OSA subjects.
Aims. i. Evaluate submaximal exercise capacity over the 6-min walk test (6MWT) data ii. Determine the factors that influence 6-min walk distance (6-MWD). iii. Compare their 6MWD with those of 2 controls groups [healthy (n=154) and obese (n=55)].
Methods. Inclusion criteria: patients with severe OSA medically stable (n=42 men, 18 women). Non-inclusion criteria: 6MWT contraindications and corticosteroid therapy. Investigations: questionnaires, polysomnography plethysmography and 6MWT.
Results. Mean±SD: age (49±10 Yr), body mass index (BMI, 37±6 kg.m^-²), apnoea hypopnoea index (62±18/h) and FEV₁ (89±17%). i. OSA subjects profile: 31% have an end walk dyspnoea ≥ 5/10, 25% have a low end-walk heart rate (< 60% of maximal predicted), 13% have a significant lower 6MWD (< lower limit of normal) and 13% have a significant oxy-haemoglobin fall (> 5 points). Estimated cardiorespiratory and muscular chain age (71±18 Yr) was significantly higher than the chronological age. ii. The factors that influence 6MWD, explaining 80% of its variability, are exposed in this equation: 6MWD (m) = 29.66xFEV₁ (l) – 4.19xBMI (kg.m^-2) – 51.89xHypertension (0. No; 1. Yes) + 263.53xHeight (m) + 2.63xAverage oxy-haemoglobin during sleep (%) – 51.06xDiuretic use (0. No; 1. Yes) – 20.68xDyspnoea (NYHA) (0. No; 1. Yes) -38.09x History of anemia (0. No; 1. Yes) + 5.79x Resting oxy-haemoglobin (%) – 586.25. iii. Compared with the healthy and obese groups, the OSA group have a significantly lower 6MWD (100±9%, 100±8% and 83±12%, respectively).
Conclusion. A program of rehabilitation training would be appropriate for OSA subjects.

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Citations should be made in the following way:
H. Ben Saad, A. Abdelghani, I. Ben Hassan, I. Ghannouchi, Z. Tabka, M. Benzarti (Sousse, Tunisia). Evaluation of submaximal exercise capacity in patients with obstructive sleep apnoea (OSA). Eur Respir J 2010; 36: Suppl. 54, 919

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