Adenosine contracts human isolated bronchi via A1 receptor dependent mechanism

L. Calzetta, M. G. Matera, C. P. Page, M. Cazzola, D. Spina (Rome, Italy; , United Kingdom)

Source: Annual Congress 2010 - Airway cells as targets for anti-inflammatory drugs
Session: Airway cells as targets for anti-inflammatory drugs
Session type: Oral Presentation
Number: 2129
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Calzetta, M. G. Matera, C. P. Page, M. Cazzola, D. Spina (Rome, Italy; , United Kingdom). Adenosine contracts human isolated bronchi via A1 receptor dependent mechanism. Eur Respir J 2010; 36: Suppl. 54, 2129

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects
Source: Eur Respir J 2008; 31: 311-319
Year: 2008



The role of CPA (adenosine A1 agonist) in airway reflexes
Source: Annual Congress 2004 - Neural regulation of airways and cough
Year: 2004


Effects of a newly developed dual CysLT1 and CysLT2 receptor antagonist, ONO-RS-531, on antigen- and leukotriene D4-induced contractions of isolated human bronchi
Source: Eur Respir J 2005; 26: Suppl. 49, 214s
Year: 2005

Insulin acutely potentiates M3 muscarinic receptor function in rat and human airway smooth muscle
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017

One component of the antigen-induced contraction of the guinea-pig trachea is mediated by serotonin acting on 5-HT2A receptors
Source: Eur Respir J 2007; 30: Suppl. 51, 620s
Year: 2007

PGD2 induces constriction of the peripheral guinea pig lung via the TP receptor
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

Increased relaxation of immature airways to beta-2 agonists is related to the attenuated expression of postjunctional smooth muscle muscarinic M2 receptors
Source: Annual Congress 2004 - Understanding the complexity of how airways are regulated
Year: 2004


The adenosine A2B receptor antagonist GS-6201 reduces small artery muscularization and plasma endothelin-1 in a short term cigarette smoke exposure model
Source: Annual Congress 2012 - Pulmonary circulation: clinical diagnosis, treatment, end-points and animal models
Year: 2012

Muscarinic receptors mediate up-regulation of endothelin-1 expression in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Hypoxia-mediated alterations in adenosine receptor expression in rat lung
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011

Muscarinic receptor dependent contraction of small airways from both rats and humans
Source: Eur Respir J 2006; 28: Suppl. 50, 432s
Year: 2006

Expression and function of PGE2 pathway enzymes and receptors in the guinea-pig trachea
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

Cigarette smoke altered the expression of choline acetyl transferase and muscarinic receptors promoting the LTB4 release from human bronchial epithelial cells
Source: Annual Congress 2008 - Airway cell biology
Year: 2008


Adenosine but not the A2A adenosine receptor agonist, CGS 21680 attenuates the endothelial cell barrier disruption induced by lipopolysaccharide
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011


Potentiation effect of insulin on M3 muscarinic receptor agonist induced airway smooth muscle contraction
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Expression and functional involvement of muscarinic receptor 3 (M3) in human lung fibroblasts in COPD
Source: Eur Respir J 2005; 26: Suppl. 49, 121s
Year: 2005

Prostacyclin IP receptor activation blocks hyperosmolar-induced bronchoconstriction in isolated human small airways
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Beyond the dogma: novel β2-adrenoceptor signalling in the airways
Source: Eur Respir J 2006; 27: 1286-1306
Year: 2006



Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells
Source: Eur Respir J 2009; 34: 1436-1443
Year: 2009



Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
Source: Eur Respir J 2008; 32: 555-562
Year: 2008