Source: Annual Congress 2010 - COPD: treatment and monitoring
Disease area: Airway diseases

Abstract

Aim: to study and analyze the blood level of fibrinogen, CRP, albumin and medium weight molecules (MWM) in COPD pts depending on severity of exacerbation.
Material and method: 65 pts with acute exacerbation of COPD (I and II types by Anthonisen) were studied. All pts were allocated on two groups: group 1 made up 17 pts (mean age 57,8 ± 1,7 yrs) with light AECOPD; group 2 – 48 pts (mean age 58,4 ± 2,1 yrs) with middle AECOPD. 20 healthy individuals with similar age and gender characteristics were included in control group. Spirometry and investigation of blood were obtained.
Results: fibrinogen‘s and CRP levels in pts of control gr. and gr.1 were comparable; in gr. 2 these parameters were significant higher than group 1 (tabl. 1). Albumin‘s level no depended on severity of exacerbation and was the same in COPD and no-COPD pts. Level of endogenous intoxication marker – MWM – was significant higher in COPD pts than in control gr., but no differ in gr. 1 and gr. 2.

Fibrinogen‘s, CRP, albumin‘s and MWM level in blood of AECOPD pts

Performance	Control group, (n=20)	Gr. 1, (n=17)	Gr. 2, (n=48)	p
Fibrinogen, g/L	2,97 ± 0,19	3,3 ± 0,08	4,1 ± 0,09*	0,0001
CRP, mg/L	2,5 ± 0,5	4,7 ± 1,3	25,4 ± 4,3*	0,0001
Albumin, g/L	47,2 ± 1,3	45,0 ± 1,1	44,7 ± 0,7	0,82
MMW, mg/L	542,0 ± 17,0	677,8 ± 19,5*	730,6 ± 19,6*	0,06

Comment: * – p<0,05 between control and this group.

Conclusion: the fibrinogen and CRP concentration may be use as markers of AECOPD severity (correlation between these parameters and severity of exacerbation consist r = 0,61, p < 0,0001 and r = 0,50, p<0,0001 appropriately.

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Citations should be made in the following way:
K. Gashynova, O. Plekhanova, T. Pertseva, E. Lykholat (Dnepropetrovsk, Ukraine). Inflammation markers: Dependence from severity of AECOPD. Eur Respir J 2010; 36: Suppl. 54, 1323

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