A decoy CXCL8 with increased glycosaminoglycan binding has potent anti-inflammatory activity in lung inflammation models

T. Adage, A. Rek, A. J. Kungl (Graz, Austria)

Source: Annual Congress 2010 - Pre-clinical models of airways disease
Session: Pre-clinical models of airways disease
Session type: Oral Presentation
Number: 5151
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Adage, A. Rek, A. J. Kungl (Graz, Austria). A decoy CXCL8 with increased glycosaminoglycan binding has potent anti-inflammatory activity in lung inflammation models. Eur Respir J 2010; 36: Suppl. 54, 5151

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cilomilast, a second generation phosphodiestease 4 inhibitor, in combination with PGE2 attenuates fMLP, IL-8 and cigarette smoke-induced effects on the mechanical and functional properties of neutrophils
Source: Eur Respir J 2001; 18: Suppl. 33, 161s
Year: 2001

Roflumilast potently inhibits CXCL1 mediated neutrophil migration in COPD patients
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

Pro- and anti-inflammatory cytokines TNF-alpha, IFN-gamma, IL-10 and TGF-beta1 levels in blood serum as markers of plasmaferesis success and inflammation activity in lung sarcoidosis (LS)
Source: Eur Respir J 2006; 28: Suppl. 50, 676s
Year: 2006

Neu-164, a novel antioxidant and anti-inflammatory compound reduces lung inflammation in a murine model of allergic asthma
Source: Annual Congress 2008 - Comorbid cardiovascular condition and therapy of asthma
Year: 2008

Dexamethasone exhibits dual response to expression and production of eotaxin in the lung fibroblast
Source: Eur Respir J 2005; 26: Suppl. 49, 551s
Year: 2005

Inhibition of LPS-induced cytokine/chemokine production from human lung macrophages by roflumilast is enabled by autocrine PGE2
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010


Small neutralizing molecules to inhibit actions of the chemokine CXCL12 and other chemokines
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


N-acetyl cysteine inhibits IL-17-induced IL-8 production from human airway smooth muscle cells - a possible role for anti-oxidant treatment in chronic lung rejection?
Source: Eur Respir J 2003; 22: Suppl. 45, 202s
Year: 2003

Neu-164, a novel antioxidant and anti-inflammatory compound, reduces cigarette smoke-induced lung inflammation
Source: Annual Congress 2008 - COPD
Year: 2008


Potent anti-inflammatory effects of the highly selective iNOS inhibitor Byk402750 in a mouse model of cigarette smoke induced inflammation
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

The anti-inflammatory effects of helminth-derived peptides in a model of endotoxin-induced acute lung injury
Source: Virtual Congress 2021 – Environmental and lifestyle impacts on chronic lung disease
Year: 2021


SDF-1 is an antifibrotic mediator in vivo
Source: Virtual Congress 2020 – Translational therapeutic advances
Year: 2020


IL-13Rα2 is necessary for in vitro anti-proliferative activity of CXCR3 ligands in mouse lung fibroblasts
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010


CCL5 (RANTES) inhibits TGF-β1-induced collagen production in human bronchial epithelial cells by action of Smad protein
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

Statins suppress LPS-induced proinflammatory cytokine production from human bronchial epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Inhibitory effect of statins on fibrogenic mediator production from lung cells
Source: Annual Congress 2012 - Diffuse parenchymal lung disease pathogenesis, biomarkers, therapy and new entities
Year: 2012


Importin-7 knockdown reduces corticosteroid induced glucocorticoid receptor nuclear localisation and suppression of IL-1beta induced CXCL8
Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management
Year: 2013

The inhibitory effect of fenretinide on the expression of inflammatory cytokines, possible molecular target of the drug and its relevance to cystic fibrosis.
Source: Research Seminar 2009 - Molecular and Cellular aspects of Chronic Lung Disease
Year: 2009

Estrogen protects against airway inflammation via upregulation of SLPI and downregulation of IL-33
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012

Resolvin E3 reduces profibrotic factor production from macrophages leading to tissue homeostasis
Source: Virtual Congress 2020 – Mechanistic insight into lung injury and repair
Year: 2020