Source: Annual Congress 2010 - Nocturnal cardiology: chronic heart failure, acute chest syndrome, coronary artery disease and collagen vascular disease
Disease area: Sleep and breathing disorders

Abstract

Obstructive Sleep Apnea Syndrome (OSAS) is an independent risk factor for the development of cardiovascular event and hypertension. The possible causes are oxygen desaturation due to apnea, hypopnea, increased cytokine levels and insulin resistance. Same risk factors also have a role in the progression of chronic kidney disease (CKD). The aim of this study was to determine the relationship between OSAS and the severity of CKD. We retrospectively evaluated the medical records of 186 subjects who were admitted for sleep study. OSAS was diagnosed by polysomnography if Apnea-Hypopnea Index (AHI) >5 and Glomerular Filtration Rate (GFR) (ml/second) was calculated with Cockcroft–Gault formula. According to AHI, individuals in whom AHI< 5 were recruited as group 1 (control group), those in whom AHI=5-15 group 2 (mild OSAS group), those in whom AHI=15-30 group 3 (moderate OSAS group), those in whom AHI >30 group 4 (severe OSAS group). Of the subjects 117 (67%) were male, 58 (33%) were female and the mean age was 54.0± 12.1years. There were 25 (14.3%), 18 (10.3%), 35 (20.0%) and 97 (55.4%) in group 1, 2, 3 and 4 respectively. There were no differences between all groups regarding age, gender, prevalence of hypertension, diabetes and previous cardiovascular event (p>0.05). A significant decrease in GFR was detected while the severity of OSAS increased (group 1= 50.0±11.8, group 2= 52.4±8.6, group 3= 44.8±15.9, group 4= 38.8±16.0; p = 0.001). We speculate that OSAS is an independent risk factor for the progression of CKD which is a growing health problem.

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A. Kanbay, H. Buyukoglan, E. Kaya, F. S. Oymak, R. Demir, I. Gulmez (Kayseri, Turkey). Obstructive sleep apnea syndrome is an independent risk factor for progression of chronic kidney disease: A new link?. Eur Respir J 2010; 36: Suppl. 54, 918

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