Source: Annual Congress 2010 - State of the art imaging
Disease area: Airway diseases

Abstract

Rationale: Exertional dyspnea and leg fatigue are the primary symptoms that limit exercise in patients with chronic obstructive pulmonary disease (COPD). It is unknown which brain area is activated in correlation with these symptoms in COPD patients.
Objective: To investigate the activation of cortical areas associated with dyspnea and leg fatigue during exercise in COPD patients.
Methods: Eight COPD patients performed mild intensity constant-work rate cycle exercise (60% of anaerobic threshold) for 10 minutes while cerebral hemodynamics and oxygenation in response to neural activation were measured by near-infrared spectroscopy (NIRS). Dyspnea and leg fatigue were also determined every minute during exercise via breath-by-breath gas exchange and ventilatory measurements. We placed three NIRS probes over the frontal and temporoparietal cortical regions of patients‘ heads and measured changes in cortical oxyhemoglobin (Oxy-Hb), deoxyhemoglobin (deoxy-Hb), and total hemoglobin (total-Hb) from baseline recordings.
Results: Oxy-Hb concentration was significantly increased in the frontal region during exercise, but not in temporoparietal regions. Dyspnea and leg fatigue scores were positively correlated with changes in oxy-Hb concentration in the frontal region. Multivariable analysis including ventilatory parameters, age, and oxygen saturation showed that dyspnea was independently correlated with oxy-Hb concentration in the upper part of the frontal region, while leg fatigue was correlated with oxy-Hb concentration in the lower part of the frontal region.
Conclusions: Exertional dyspnea and leg fatigue were related to activation of frontal cortical regions in COPD.

Rating:

Share or cite this content

Citations should be made in the following way:
Y. Higashimoto, N. Honda, T. Yamagata, R. Satoh, O. Nishiyama, H. Sano, T. Iwanaga, T. Miyara, M. Muraki, K. Tomita, H. Kume, K. Fukuda, Y. Tohda (Osakasayama, Japan). Cortical activation during constant-work rate cycle exercise in COPD patients: Relation to exertional dyspnea. Eur Respir J 2010; 36: Suppl. 54, 5278

Member's Comments

No comment yet.

Related content which might interest you: Cortical activation associated with exertional dyspnea during constant-work rate cycle exercise in healthy subjects Source: Annual Congress 2010 - Thoracic dynamics and dyspnoea on exercise Year: 2010 Effects of oxygen on exertional dyspnea and exercise performance in patients with COPD Source: Annual Congress 2011 - Clinical physiology for clinical problems Year: 2011 Mechanisms of exertional dyspnoea in COPD and heart failure patients matched by peak aerobic capacity Source: International Congress 2019 – Exercise physiopathology in various respiratory diseases Year: 2019 Severe exertional dyspnoea in COPD: Implications for exercise tolerance and survival Source: Virtual Congress 2021 – New insights into the pathophysiology and prognosis of COPD Year: 2021 Relationship between respiratory metabolism and dyspnea during inspiratory muscle training in stable COPD patients Source: Annual Congress 2008 - Physiological response to exercise performance Year: 2008 Effect of pulmonary rehabilitation (PR) on exertional dyspnea and dynamic hyperinflation during six minute walk test in COPD patients Source: Eur Respir J 2004; 24: Suppl. 48, 209s Year: 2004 Effects of arm training on exertional dyspnoea in patients with COPD Source: Eur Respir J 2002; 20: Suppl. 38, 66s Year: 2002 Breathing pattern and post-exercise inspiratory muscle fatigue in COPD: Comparing step tests and cycle ergometry Source: International Congress 2018 – Exercise is medicine: testing and treating patients with some effort Year: 2018 Ventilatory adaptation to eccentric cycling in moderate to severe COPD patients Source: International Congress 2016 – From cardiopulmonary interaction to locomotor muscles and dyspnoea in health and disease Year: 2016 Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD Source: Eur Respir J 2009; 34: 866-874 Year: 2009 Mechanism of improvement of exertional dyspnea during six minute walking test (6MWT) after pulmonary rehabilitation (PR) in COPD Source: Eur Respir J 2005; 26: Suppl. 49, 719s Year: 2005 Resting V?E / V?CO2 is a strong predictor of exertional dyspnoea in COPD Source: International Congress 2019 – Exploring exercise responses in respiratory diseases Year: 2019 Effect of biventricular pacing on cardioventilatory responses, exertional dyspnea and exercise capacity in patients with stable chronic heart failure Source: Annual Congress 2007 - Mechanisms of exercise intolerance in cardiorespiratory disease Year: 2007 Positive expiratory pressure breathing accelerates recovery of exertional dyspnea in participants with COPD: A randomised cross over trial Source: International Congress 2016 – Pathophysiological mechanisms at different levels: lung, airways, muscles and symptom perception Year: 2016 Analysis of autonomic modulation after an acute session of aerobic exercise at different intensities in patients with moderate and severe COPD Source: International Congress 2015 – Pathophysiological mechanisms at different scales: lung, airways, muscles and symptom perception Year: 2015 Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management Year: 2013 Exertional dyspnoea and cortical oxygenation in patients with COPD Source: Eur Respir J 2015; 46: 1615-1624 Year: 2015 Exercise endurance in severe COPD patients: Importance of the power-duration relationship Source: Annual Congress 2010 - Exercise in COPD Year: 2010 Endogenous opioids modify dyspnoea during treadmill exercise in patients with COPD Source: Eur Respir J 2009; 33: 771-777 Year: 2009 Comparison of functional exercise capacity respiratory and peripheral muscle strength, dyspnea and fatigue in over and normal Weighted COPD patients Source: Annual Congress 2013 –Exercise, physiotherapy techniques and assessment methods in COPD and asthma Year: 2013