Source: Annual Congress 2010 - Novel approach in diagnosis and treatment of pleural effusions

Abstract

Pleural fluids(PF) develop due to several reasons. Nowadays, Light criteria‘s are used to differentiate transudative and exudative pleural effusions. However, Light criteria‘s could fail in some situations.
This study was performed to research the role of the PF and serum NT-proBNP levels in differential diagnosis of pleural effusions.
Ninety-one patients with pleural effusion were included in this study. 23 patients with PF secondary to heart failure(Group 1), 25 patients with noncardiac transudative PF (Group 2) and 43 patients with exudative PFdue to other problems(Group 3). PF NT-proBNP and serum NT-proBNP levels were performed in all patients as well as Light‘s criteria‘s. PF and serum NT-proBNP levels were increased(p< 0,001) in Group 1 patients. Significant correlation was found between serum and blood NT-proBNP levels(p< 0,05). Serum NT-proBNP and PF NT-proBNP levels were increased in Group 2(p< 0,001).
Our study demonstrated that both of serum and PF NT-proBNP assays could differentiate cardiac PF. We suggest that serum NT-proBNP assay could be more preferable to thorasynthesis in patients who are suggesting heart failure clinically. Moreover, serum and PF NT-proBNP assays could play an important role in differential diagnosis of exudative PF secondary to renal failure which have exudative PF according to Light criteria‘s.

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Citations should be made in the following way:
F. O. Ergur, G. Ulubay, N. Bayraktar (Ankara, Turkey). Value of pleural fluid and serum NT-ProBNP levels in differentiation of transudative and exudative pleural effusions. Eur Respir J 2010; 36: Suppl. 54, 228

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