Source: Annual Congress 2005 - Skeletal muscles: current concepts
Disease area: Airway diseases

Abstract

Skeletal muscle depletion is a significant complication affecting patients with chronic obstructive pulmonary disease which has a complex aetiology. Quadriceps strength in these patients has been shown to be associated with angiotensin converting enzyme (ACE) gene polymorphism. We hypothesized that might therefore be a link between quadriceps strength and the (+9/-9) polymorphism of the bradykinin receptor (BK₂R) since this has previously been shown to influence metabolic exercise efficiency and left ventricular hypertrophy in response to training. We studied 110 patients with a mean(SD) FEV₁ 34.3(16.4)%predicted and 104 healthy age-matched controls. In patients who were homozygotes for the +9 allele (n=37), which is associated with lower receptor levels, isometric quadriceps strength was significantly lower 30.8(10.4)kg vs 36.4(12.8)kg p=0.02, as was fat free mass index; 15.7(1.8)kg.m^-2 vs 16.6(2.3)kg.m^-2 (p=0.04). There was no evidence of an interaction with ACE genotype. Bradykinin receptor genotype did not influence any parameter measured in the control group. A higher level of the receptor appears to preserve fat free mass and strength in patients with chronic obstructive pulmonary disease.
Supported by The Wellcome Trust and The European Union ENIGMA project

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N. S. Hopkinson, A. Eleftheriou, J. Payne, A. H. Nickol, E. Hawe, J. Moxham, H. Montgomery, M. I. Polkey (London, United Kingdom). Bradykinin receptor gene polymorphism and quadriceps strength in COPD. Eur Respir J 2005; 26: Suppl. 49, 1665

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