Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2, via activation of p38 mitogen-activated protein kinase

K. E. Hostettler, P. Borger, J. Zhong, J. K. Burgess, J. L. Black, M. Roth (Sydney, Australia; Basel, Switzerland)

Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms
Session: Pulmonary hypertension and fibrosis: novel mechanisms
Session type: Oral Presentation
Number: 1626
Disease area: Interstitial lung diseases, Pulmonary vascular diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. E. Hostettler, P. Borger, J. Zhong, J. K. Burgess, J. L. Black, M. Roth (Sydney, Australia; Basel, Switzerland). Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2, via activation of p38 mitogen-activated protein kinase. Eur Respir J 2005; 26: Suppl. 49, 1626

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Transforming growth factor-α (TGF-α)-induced interleukin-8 (IL-8) release in human bronchial epithelial cells in vitro: role of mitogen-activated protein kinases (MAPK)
Source: Eur Respir J 2002; 20: Suppl. 38, 573s
Year: 2002

Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway
Source: Eur Respir J 2008; 31: 523-531
Year: 2008



Effects of TGF-beta and budesonide on MAPK phosphorylation, IL-6/IL-11 secretion, and cell proliferation in human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006

Inhibitory effects of the IL-6 receptor superantagonist SANT7 on MAP kinase phosphorylation and cell proliferation induced by IL-6 and TGF-beta1 in human lung fibroblasts
Source: Annual Congress 2008 - Clinical aspects of interstitial lung disease
Year: 2008

Effects of endothelin-1 on MAPK activation, IL-6 production and cell proliferation in normal human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

Bone morphogenetic proteins (BMPs) inhibit hypoxia stimulated human pulmonary artery fibroblast (PAF) proliferation via inhibition of p38 MAP kinase and HIF-1α
Source: Annual Congress 2004 - Pathophysiology of pulmonary hypertension
Year: 2004


Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells
Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment
Year: 2011


Corticosteroids reduce pro-inflammatory cytokine expression in airway smooth muscle cells via upregulation of MAPK phosphatase-1 and inhibition of p38 MAPK signalling
Source: Eur Respir J 2005; 26: Suppl. 49, 713s
Year: 2005

Bradykinin phosphorylates ERK1/2 through epidermal growth factor receptor transactivation in human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 341s
Year: 2005

Jun kinase regulates the expression of TGF-beta induced connective tissue growth factor in human lung fibroblast
Source: Annual Congress 2004 - Inflammation and remodelling in human lungs
Year: 2004


Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages
Source: Eur Respir J 2004; 23: 805-812
Year: 2004



YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK, ERK1/2) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012


Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Thrombin induces stomatin-like protein 2 (STOML2) expression and IL-8/CXCL8 release by ROCK, JNK, and PEA3 pathways in human lung epithelial cells
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020

Differential role of EPAC and PKA in the transduction of cAMP-mediated inhibition of human lung fibroblast proliferation and collagen synthesis
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


Effects of glucocorticoids on activation of extracellular signal-regulated kinases (ERK) in human pulmonary endothelial cells
Source: Eur Respir J 2001; 18: Suppl. 33, 160s
Year: 2001

N-acetylcysteine reduces chemokine release via inhibition of p38 MAPK in human airway smooth muscle cells
Source: Eur Respir J 2003; 22: 43-49
Year: 2003



Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence or presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005

Activation of second messenger pathways in alveolar macrophages by endotoxin
Source: Eur Respir J 2002; 20: 210-222
Year: 2002