Comparison of the release characteristics of formoterol dihydrate powder for inhalation delivered through two different types of multidose dry powder inhalers (MDPI)
B. Bidlingmaier, S. Mueller, B. Fyrnys (Bad Homburg, Germany)
Source: Annual Congress 2005 - Inhaler devices: challenges and solutions
Session: Inhaler devices: challenges and solutions
Session type: Thematic Poster Session
Number: 858
Disease area: Airway diseases
Abstract We compared the release characteristics of two different types of MDPIs, NOV (Formatris® Novolizer® ) and AER (Foradil® P Aerolizer® ). We assessed the delivered dose and the aerodynamic particle size distribution of the fine particle dose of formoterol fumarate dihydrate powder for inhalation. The two devices have significantly different airflow resistances due to their different constructions. These differences in airflow resistance result in different pressure drops for each MDPI at a defined inspiratory flow rate. The release characteristics of both devices were assessed at defined pressure drops to ensure comparability of the results, because the pressure drop is generated by the inspiratory effort of the patient. For both devices, the results show only a slight dependence of the delivered dose on the pressure drop in the range of 2-5 kPa. In comparison, the delivered dose through the NOV was consistently higher than that delivered through the AER. The complete release of powder through the device is essential for the correct use of the inhaler by the patient. The fine particle doses for both the NOV and the AER were comparable and as for almost all breath-actuated dry powder devices slightly dependent on the pressure drop and thus on the corresponding airflow rate. Thus, more reliable dosing of NOV (Novolizer® ) can be assumed from these in-vitro results.
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B. Bidlingmaier, S. Mueller, B. Fyrnys (Bad Homburg, Germany). Comparison of the release characteristics of formoterol dihydrate powder for inhalation delivered through two different types of multidose dry powder inhalers (MDPI). Eur Respir J 2005; 26: Suppl. 49, 858
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