Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice

Arai N., Kondo M., Izumo T., Tamaoki J., Nagai A.

Source: Eur Respir J 2010; 35: 1164-1171
Journal Issue: May
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Arai N., Kondo M., Izumo T., Tamaoki J., Nagai A.. Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice. Eur Respir J 2010; 35: 1164-1171

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
CC chemokine receptor 3 inhibitor, antileukinate, suppressed ovalbumin induced goblet cell metaplasia and airway hyperresponsiveness in mice
Source: Annual Congress 2005 - Basic mechanisms in asthma and COPD: new insights
Year: 2005


Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD
Source: Eur Respir J 2007; 29: 914-922
Year: 2007



Therapeutic effect of roflumilast on LPS- and OVA-induced goblet cell hyperplasia in rats
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

Suplatast tosilate decreases goblet cell metaplasia in patients with asthma
Source: Annual Congress 2006 - Established and experimental therapies for allergic asthma
Year: 2006

IL-8 and TSLP production as markers of bronchial epithelial cell activation in IL-17A mediated airway inflammation in COPD: Role of tiotropium
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Azithromycin increases phagocytosis of apoptotic airway epithelial cells by alveolar macrophages in vitro
Source: Annual Congress 2005 - Cellular and molecular approaches to lung injury research
Year: 2005


Effect of a neutrophil elastase inhibitor on airway goblet cell secretion in sensitized guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 247s
Year: 2001

Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation
Source: Eur Respir J 2002; 19: 1142-1150
Year: 2002



Tiotropium inhibits airway inflammation and goblet cell metaplasia in a model of relapsing asthma in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps
Source: Eur Respir J 2004; 24 : 594-600
Year: 2004



IP-10 decreases TNFα-induced mucin secretion in airway epithelial cell
Source: Eur Respir J 2006; 28: Suppl. 50, 827s
Year: 2006

Less eosinophilic inflammation and goblet cell metaplasia in IL-33-treated, diet-induced obese mice
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages
Source: Eur Respir J 2006; 28: 486-495
Year: 2006



Tiotropium and fluticasone inhibit rhinovirus-induced mucin production via multiple mechanisms in differentiated airway epithelial cells
Source: Virtual Congress 2020 – Host-microbe interactions and their influence on lung disease onset and severity
Year: 2020


Pathophysiology of asthma
Source: ISSN=1025-448x, ISBN=1-904097-26-x, page=84
Year: 2003

Airway inflammation: assessment of neutrophil apoptosis in induced sputum
Source: Annual Congress 2005 - Acute and chronic infections in COPD
Year: 2005


Inflammatory cytokines in airway secretions from patients with cystic fibrosis contribute to airway epithelial cell damage
Source: Eur Respir J 2004; 24: Suppl. 48, 384s
Year: 2004

Recruitment of eosinophils and increased expression of mast cells tryptase in the bronchial mucosa of patients with allergic asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 508s
Year: 2002