A phase 1B/2A study to evaluate the effect of aerosolized, recombinant alpha 1-antitrypsin (rAAT) on epithelial lining fluid (ELF) analytes in subjects with AAT deficiency Source: Eur Respir J 2005; 26: Suppl. 49, 287s Year: 2005
Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI Source: Eur Respir J 2004; 24: Suppl. 48, 471s Year: 2004
Alpha 1-Antitrypsin deficiency (AATD) in patients with ARDS consequent to SARS-CoV-2 infection. Source: Virtual Congress 2021 – COVID – 19: treatments and predictive factors Year: 2021
Intra-epithelial polymerization, accumulation and secretion of alpha1 antitrypsin (AAT) Z polymers in the lung of patients with alpha-1 antitrypsin deficiency (AATD) Source: Annual Congress 2010 - Epithelial cell biology Year: 2010
Alpha 1 antitrypsin (A1AT) deficiency among patients with cystic fibrosis Source: Eur Respir J 2003; 22: Suppl. 45, 501s Year: 2003
Phase I safety investigation of an aerosolized, recombinant alpha 1-antitrypsin in subjects with alpha 1-antitrypsin deficiency Source: Eur Respir J 2004; 24: Suppl. 48, 228s Year: 2004
Reduction in incidence of exacerbations in patients with alpha 1 antitrypsin deficiency (A1ATD) treated with concentrates of alpha 1 antitrypsin (A1AT): REXA study Source: Annual Congress 2011 - Biomarkers and exacerbations of asthma and COPD Year: 2011
Alveolar nitric oxide correlates with lung volumes in patients with emphysema and Alpha-1 antitrypsin deficiency (AATD) Source: Eur Respir J 2006; 28: Suppl. 50, 223s Year: 2006
Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette-induced lung damage in the smoking mouse model Source: Annual Congress 2004 - Insights into asthma and COPD Year: 2004
Immune activation in α1 antitrypsin deficiency (AATD) emphysema: Beyond the protease/antiprotease hypothesis Source: Annual Congress 2012 - Mechanistic studies in airway cell biology Year: 2012
Estimated numbers and prevalence of PI*S and PI*Z deficiency alleles of α1-antitrypsin deficiency in Asia Source: Eur Respir J 2006; 28: 1091-1099 Year: 2006
Neutrophil elastase gene expression and relation with lung function in Alpha-1 Antitrypsin deficiency patients. Source: International Congress 2017 – Current molecular and genetic understanding of lung diseases Year: 2017
Variability of sputum inflammatory mediators in COPD and ?1-antitrypsin deficiency}, Source: Eur Respir J 2012; 40: 561-569 Year: 2012
Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD) Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease Year: 2003
Lung function in relation to emphysema development in alpha-1 antitrypsin deficiency Source: International Congress 2019 – Insights into physiological diagnostic services Year: 2019
Alpha 1-antitrypsin deficiency Source: Breathe 2008; 4: 377-380 Year: 2008
α1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients Source: Eur Respir J 2007; 29: 240-250 Year: 2007
Ventilation inhomogeneity is correlated with biomarkers of parenchymal destruction in alpha1 antitrypsin deficiency Source: Eur Respir J 2007; 30: Suppl. 51, 620s Year: 2007
Alpha-1 antitrypsin genotypes and associated inhibitory activity towards neutrophil serine proteinases, in vivo Source: International Congress 2015 – Translational research in respiratory care: new findings Year: 2015
Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency Source: Eur Respir J 2009; 33: 354-360 Year: 2009