Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD)
J. R. Topping, E. J. Vanden Bon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda)
Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
J. R. Topping, E. J. Vanden Bon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda). Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD). Eur Respir J 2003; 22: Suppl. 45, 159
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Human macrophage elastase (MMP-12) expression in human emphysematous lungs: role in extracellular matrix remodelling in chronic obstructive pulmonary diseases (COPD) Source: Eur Respir J 2001; 18: Suppl. 33, 501s Year: 2001
Elevation of neutrophil collagenase (MMP-8) and elastase during COPD exacerbation Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD Year: 2008
Concentration of NO2-, a-acid protein (AAP), tumor necrotic factor (TNF-a), in the induced sputum of patients with bronchial asthma(BA) and chronic obstructive bronchitis (COB) Source: Eur Respir J 2001; 18: Suppl. 33, 367s Year: 2001
Relationship between circulating serpina 3g, activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, 2 with chronic obstructive pulmonary disease severity Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD Year: 2018
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients Source: Eur Respir J 2005; 25: 885-890 Year: 2005
Relationship between Candida strains colonization and MMP-9 and TIMP-1 induced sputum concentration in chronic obstructive pulmonary disease‘s (COPD) patients and healthy control group Source: Annual Congress 2010 - Colonisation and infection in COPD Year: 2010
Relationship between MMP-9 and TIMP-1 induced sputum concentration and the stage of chronic obstructive pulmonary disease‘s (COPD) Source: Annual Congress 2008 - Issues in the management of COPD in the community Year: 2008
The effect of sputum processing on tumour necrosis factor (TNFα), secretory leukoprotease inhibitor (SLPI), interleukin-6 and leukotriene-B4 (LTB4 ) in chronic bronchitis and bronchiectasis Source: Eur Respir J 2001; 18: Suppl. 33, 364s Year: 2001
The expression of MMP2, 9 and TIMP1 mRNA in bronchoalveolar cells of patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases Year: 2009
Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space Source: Eur Respir J 2008; 32: 644-650 Year: 2008
Matrix metalloproteinases (MMPs), tissue inhibitor of matrix metalloproteinases (TIMPs) and transforming growth factor-β (TGFβ) expression in small airways (SA) of usual idiopathic pneumonia (UIP), non-specific interstitial pneumonia (NSIP), hip Source: Annual Congress 2007 - Role of genomics and biological tools in the work-up of interstitial lung disease Year: 2007
Production of matrix metalloprotease-9 (MMP-9) by alveolar macrophages (AMs) from smokers: effect of corticosteroids and phosphodiesterase inhibition Source: Eur Respir J 2001; 18: Suppl. 33, 34s Year: 2001
Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI Source: Eur Respir J 2004; 24: Suppl. 48, 471s Year: 2004
MMP2, 8, 9 and TIMP1-4 levels in bronchoalveolar fluid of patients with chronic obstructive pulmonary disease and bronchial asthma Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung Year: 2010
Measurement of tumor necrosis factor (TNF)α, leukotriene B4 (LTB4), and interleukin 8 (IL8) in the exhaled breath condensate (EBC) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) Source: Eur Respir J 2007; 30: Suppl. 51, 584s Year: 2007
Increased levels of human myeloperxidase (MPO) and neutrophil lipocalin (HNL/NGAL) in childhood asthma Source: International Congress 2019 – Understanding, monitoring and targeting severe asthma Year: 2019
Increased expression of phosphodiesterase 4 (PDE4) A, B and D in alveolar macrophages from chronic obstructive pulmonary disease (COPD) patients Source: Annual Congress 2011 - Macrophages and neutrophils in chronic lung disease Year: 2011
Enhanced expression of proinflammatory cytokine (IL-18) and its receptor in patients with chronic obstructive pulmonary disease (COPD) Source: Eur Respir J 2006; 28: Suppl. 50, 551s Year: 2006
Increased neutrophil gelatinase-associated lipocalin (NGAL) promotes airway remodeling in chronic obstructive pulmonary disease (COPD) Source: International Congress 2016 – Laboratory tests and cell biology in allergy and immunology Year: 2016
Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD Source: Eur Respir J 2013; 41: 1042-1050 Year: 2013