Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice

Genki Kimura (Funabashi, Japan), Genki Kimura, Yuki Nishimoto, Keitaro Ueda, Takahiro Nakaoki, Takashi Masuko, Peter J. Barnes, Kazuhiro Ito, Yasuo Kizawa

Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Session: Novel mechanisms and treatment modalities in asthma
Session type: Poster Discussion
Number: 4896
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Genki Kimura (Funabashi, Japan), Genki Kimura, Yuki Nishimoto, Keitaro Ueda, Takahiro Nakaoki, Takashi Masuko, Peter J. Barnes, Kazuhiro Ito, Yasuo Kizawa. Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice. Eur Respir J 2016; 48: Suppl. 60, 4896

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
BmTI-A: A serine protease inhibitor attenuates hyperresponsiveness in an experimental model of chronic allergic inflammation in Balb/c mice
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

Vitamin C inhibits the diisocyanate-induced lung inflammatory response in mice
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

Acid sphingomyelinase deficiency improves lung function in allergen-induced asthma in mice
Source: Annual Congress 2013 –Cell biology and murine models of asthma and inflammation
Year: 2013

Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Effects of acute hypochlorite exposure in OVA-sensitized and challenged mice
Source: International Congress 2015 – Occupational and environmental effects: in vitro and animal models
Year: 2015


BmTI-A, a serine protease inhibitor, reduces the chronic allergic lung inflammation in a mice model
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

Repeated lipopolysaccharide stimulation causes corticosteroid insensitive inflammation in lung via phosphoinositide-3-kinase δ signaling
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Effects of LTRA on T cell-induced bronchoconstriction in the mice
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015

Rapamycin protects OVA induced asthma in mice through regulating autophagy
Source: International Congress 2015 – Exploring mechanisms in obstructive airway diseases
Year: 2015

Immunohistochemical study on changes of mast cell populations during allergic airway inflammation in mice using HDM model
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015


Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


The effect of lipopolysaccharide-contaminated ovalbumin on airway inflammation and remodeling in a chronic murine asthma model
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013


Influenza induced exacerbation is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice
Source: International Congress 2016 – Immune responses in the lung
Year: 2016


Autoimmune induction of a COPD-like inflammatory phenotype in mice
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

LATE-BREAKING ABSTRACT: Protective effects of surfactant protein D (SP-D) treatment in 1,3-ß-glucan-modulated allergic inflammation
Source: International Congress 2015 – Emerging strategies for airway disease treatments
Year: 2015

Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

IL-37 requires IL18Rα and SIGIRR to diminish experimental allergic airway inflammation in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Preventative administration of IL-27 improves airway inflammation of ovalbumin –induced asthma mice model via both STAT1 and GADD45γ/p38MAPK pathways
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016


PI3Kδ inhibition confer efficacy in experimental models of allergic airway inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015


LATE-BREAKING ABSTRACT: Inhibition of TRPA1 reduces airway inflammation and airway hyper-responsiveness in a murine model of allergic rhinitis
Source: International Congress 2016 – Novel mechanisms and therapeutic targets in acute and chronic inflammatory disease
Year: 2016