Correctors and potentiators: to treat patients with individual mutations

E. Kerem (Jerusalem, Israel)

Source: Annual Congress 2011 - New promising ways to treat cystic fibrosis
Session: New promising ways to treat cystic fibrosis
Session type: Symposium
Number: 1379

Slide presentationMultimedia files

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Kerem (Jerusalem, Israel). Correctors and potentiators: to treat patients with individual mutations. Annual Congress 2011 - New promising ways to treat cystic fibrosis

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Treatment of patients with non-gating mutations with potentiators
Source: International Congress 2015 – Advancing therapies for cystic fibrosis
Year: 2015



Tolerance and efficacy of antifibrotic treatments in IPF patients carriying telomere related gene mutations
Source: International Congress 2019 – Towards a better understanding of rare diffuse parenchymal lung diseases
Year: 2019



Late-breaking abstract: VX-770, an investigational CFTR potentiator, in subjects with CF and the G551D mutation
Source: Annual Congress 2011 - Cystic fibrosis: detection and monitoring of early lung disease
Year: 2011


Description of new CFTR gene’s mutations in patients of Russia
Source: Virtual Congress 2020 – Cystic fibrosis
Year: 2020


How to manage side-effects of targeted therapies?
Source: Annual Congress 2010 - PG7 Postgraduate Course: How to manage treatment complications of lung cancer
Year: 2010



Targeting targeted therapies: more choices and the best sequences
Source: International Congress 2018 – New drugs, strategies and research designs for advanced non-small cell lung cancer
Year: 2018


Improved CFTR and lung function with VX-770, a novel investigational potentiator of CFTR, in subjects with the G551D-CFTR mutation
Source: Annual Congress 2010 - Cystic fibrosis: new targets for therapy and impact of viral infections
Year: 2010


Pattern of drug resistance among patients who fail Cat II regimen and patients who fail standard treatment: is there any difference?
Source: Eur Respir J 2006; 28: Suppl. 50, 378s
Year: 2006

Predictive factors: can we identify patients who will benefit from a specific treatment?
Source: Annual Congress 2011 - Prognostic and predictive factors in lung cancer
Year: 2011


Therapeutic response in COPD patients with CFTR R75Q variant and mEPHX "slow" allele – is there a difference?
Source: Eur Respir J 2006; 28: Suppl. 50, 30s
Year: 2006

Effects of the CFTR potentiator, ivacaftor, in two phase 3 trials in subjects with CF who have the G551D-CFTR mutation
Source: Annual Congress 2012 - Cystic fibrosis (adults and children): new therapies and detection of early lung disease
Year: 2012


Second-line injectables: are they essential to treat MDR/XDR-TB cases?
Source: Annual Congress 2008 - Multidrug-resistant and the emerging threat of extensively drug-resistant tuberculosis
Year: 2008



Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles
Source: ERJ Open Res, 5 (2) 00082-2019; 10.1183/23120541.00082-2019
Year: 2019



Late Breaking Abstract: GRC 17536, a novel, selective TRPA1 antagonist for potential treatment of respiratory disorders
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Rare pulmonary diseases and orphan drugs: where do we stand and where are we going to?
Source: Eur Respir Rev 2015; 24: 375-377
Year: 2015


Carriers of a single CFTR mutation are asymptomatic: an evolving dogma?
Source: Eur Respir J, 56 (3) 2002645; 10.1183/13993003.02645-2020
Year: 2020



Are KRAS mutations druggable?
Source: New biomarkers, molecules and therapeutic sequences for non small cell lung carcinoma in the era of precision medicine
Year: 2019



Failure of EGFR TKI treatment: mechanisms and current strategies?
Source: ERS Research Seminar
Year: 2015


CFTR correctors and potentiators: pre-clinical studies in mouse models for CF
Source: Research Seminar 2009 - Molecular and Cellular aspects of Chronic Lung Disease
Year: 2009

Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis
Source: Eur Respir J 2011; 37: 59-69
Year: 2011