Molecular pathogenesis: focus on COPD and asthma

Electronic Poster Discussion
Chairs: G. Anderson (Parkville, Australia), C. Kaehler (Innsbruck, Austria)

Alpha1-antitrypsin regulates CD14 expression and soluble CD 14 levels in human monocytes in vitro I. Nita, S. Janciauskiene (Malmö, Sweden)
Strain difference in protein expression in lungs of mice after cigarette smoke exposure S. Fineschi, R. Cianti, L. Bini, G. De Cunto, G. Lungarella, G. Villetti, E. Cavarra (Siena, Parma, Italy)
Transforming growth factor beta in serum and bronchoalveolar lavage of COPD patients E. Surkova, N. Kuzubova, T. Ses, A. Totolian (Saint-Petersburg, Russian Federation)
Cigarette smoke irreversibly binds to glutathione in airway epithelial cells M. van der Toorn, M. P. Smit-de Vries, H. G. de Bruin, N. Abello, A. J. M. van Oosterhout, R. Bisschoff, H. F. Kauffman, D. J. Slebos (Groningen, Netherlands)
Compartment-specific expression of TGF-β responsive genes in an animal model of emphysema L. Farkas, K. Ask, J. Gauldie, M. Kolb (Hamilton, ON, Canada)
Measurement of neutrophil activity following acute cigarette smoking in heavy smokers with and without COPD H. Jones, N. Marks, W. Sarah, K. Laura, C. John, V. Rupert, B. Howard, S. Robert, I. Philip, B. Alan (London, United Kingdom; Philadelphia, United States Of America)
Antioxidant properties of mate tea in mouse lung exposed to cigarette smoke S. Santos Valenca, M. Lanzetti, F. Silva Bezerra, W. Alves Pimenta, L. Cristóvão Porto (Rio de Janeiro, RJ, Brazil)
Effect of non-steroidal anti-inflammatory drugs on neutrophil recruitment, p38 map kinase phosphorylation and NF-κB activation in lung from mice exposed to cigarette smoke P. Castro, H. Nasser, A. Abrahão, Jr., S. Santos Valenca, L. Cristóvão Porto, V. Koatz (Rio de Janeiro, RJ, Brazil)
Mouse models for studying respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) and desquamative interstitial pneumonia (DIP) M. Lucattelli, B. Lunghi, G. De Cunto, G. Lungarella (Siena, Italy)
Exhaled bimarkers in exacerbation of COPD A. Nielepkowicz, J. Marczak, A. Pekala-Wojciechowska, A. Baranowska, P. Gorski, W. Piotrowski, A. Antczak (Lodz, Poland)
Surfactant proteins in elastase-induced emphysema – change after ATRA treatment? A. Plagens, J. Prakash Muyal, A. O. Yildirim, H. Fehrenbach, C. Vogelmeier, C. Seifart (Marburg, Germany)
Matrix-independent expression of novel markers during transdifferentiation of primary alveolar epithelial cells M. Konigshoff, J. Milosevic, A. Jayachandran, J. Sevilla-Perez, O. Eickelberg (Giessen, Germany)
TGFβ overproduction in asthma reduces the epithelial repair by down-regulating the leptin/leptin receptor pathway A. Bruno, E. Pace, M. Profita, G. Chiappara, M. La Guardia, G. Bonsignore, P. Chanez, M. Gjomarkaj (Palermo, Italy; Montpellier, France)
Airway remodeling in severe asthmatics with fixed or variable airflow obstruction M. Kaminska, S. Foley, C. Storness-Bliss, H. Coxson, C. Lemiere, R. Olivenstein, P. Ernst, Q. Hamid, J. Martin (Montreal, QC, Vancouver, BC, Canada)
Transbronchial fibroblasts from mild asthmatics have different proteoglycan production and migratory properties compared to transbronchial fibroblasts from rhinitis patients K. Nihlberg, A. Andersson Sjöland, L. Bjermer, G. Westergren-Thorsson (Lund, Sweden)
p63 and notch signalling in asthmatic epithelial cells A. Kicic, P. McNamara, E. Sutanto, D. Knight, T. Hallstrand, S. Stick (Perth, Western Australia, Australia; Liverpool, Mereyside, United Kingdom; Vancouver, BC, Canada; Seattle, United States Of America)
Osteopontin blockade prevents fibrosis in a murine chronic model of allergic airway disease D. Simoes, G. Xanthou, K. Petrochilou, V. Panoutsakopoulou, C. Roussos, C. Gratziou (Athens, Greece)
TGF-β1 induces epithelial-to-mesenchymal transition of A549 cells Y. I. Hwang, C. H. Kim, Y. B. Park, M. G. Lee, D. G. Kim (Seoul, Republic Of Korea)
The mesenchymal gene, ADAM33, is not expressed during TGFβ-induced epithelial-mesenchymal transition (EMT) in lung epithelial cells Y. Yang, H. M. Haitchi, S. Holgate, D. Davies (Southampton, United Kingdom)