Potent anti-inflammatory effects of the highly selective iNOS inhibitor Byk402750 in a mouse model of cigarette smoke induced inflammation Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD Year: 2008
Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control Year: 2018
ERK MAP kinase is upregulated in pulmonary emphysema and mediates MMP-1 induction by cigarette smoke Source: Eur Respir J 2004; 24: Suppl. 48, 437s Year: 2004
α,β-unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through MAP kinases activation Source: Annual Congress 2009 - Airway inflammation and host defence Year: 2009
PDE4 inhibition prevents corticosteroid-resistant lung inflammation induced by cigarette smoke exposure in mice Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury Year: 2009
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma Source: Eur Respir J 2010; 35: 750-756 Year: 2010
A selective MMP-12 inhibitor, MV062926, reduces inflammatory responses to cigarette smoke in mice Source: Annual Congress 2010 - Pre-clinical models of airways disease Year: 2010
Cilomilast, a second generation phosphodiestease 4 inhibitor, in combination with PGE2 attenuates fMLP, IL-8 and cigarette smoke-induced effects on the mechanical and functional properties of neutrophils Source: Eur Respir J 2001; 18: Suppl. 33, 161s Year: 2001
Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages Source: Eur Respir J 2004; 23: 805-812 Year: 2004
Cigarette smoke upregulates IL-8/CXCL8 expression by augmenting mRNA stability via p38 MAPK/MK2 signalling in normal human pulmonary cells Source: Annual Congress 2012 - Basic and translational studies in COPD Year: 2012
17-beclomethasone monopropionate or inhibition of MAPK p38 signalling abolish IL-8 release stimulated by cigarette smoke extract or acrolein in normal human airway smooth muscle cells Source: Annual Congress 2010 - Airway smooth muscle cells Year: 2010
A combination of erythromycin and dexamethasone reduces inflammatory effects of exposure to cigarette smoke extract through modulation of Akt and histone deacetylase 2 Source: International Congress 2014 – Clinical problems in acute and chronic lung diseases Year: 2014
Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents Year: 2017
Lack of RTP801, a suppressor of the mTOR pathway, attenuates cigarette smoke-induced pulmonary injuries in mice Source: Eur Respir J 2007; 30: Suppl. 51, 140s Year: 2007
Cigarette smoke extract reduces VEGF in primary human airway epithelial cells Source: Eur Respir J 2009; 33: 835-843 Year: 2009
The effects of oral p38 mitogen activated protein kinase (MAPK) inhibitor SB-681323 on blood biomarkers in COPD Source: Annual Congress 2008 - Novel treatments for respiratory disease Year: 2008
Differential modification in the generation of IL-8 and GM-CSF by p38MAPK, MKK-1 and histone deacetylase activity in IL-1[β]-stimulated human monocytes from non-smokers, smokers and patients with COPD Source: Eur Respir J 2002; 20: Suppl. 38, 87s Year: 2002
Cigarette smoke extract (CSE) promotes acetylcholine (ACh) mediated inflammation and oxidative stress by PEBP1/Raf-mediated MEK and ERK pathway in human bronchial epithelial cells Source: International Congress 2015 – New data on established treatments for asthma and COPD Year: 2015
Neu-164, a novel antioxidant and anti-inflammatory compound, reduces cigarette smoke-induced lung inflammation Source: Annual Congress 2008 - COPD Year: 2008
RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-a and -? selectivity, suppresses COPD inflammation Source: Eur Respir J, 50 (4) 1700188; 10.1183/13993003.00188-2017 Year: 2017