ERS International Congress, Paris 2018

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Citations should be made in the following way: Authors. Title. Eur Respir J 2018; 52: Suppl. 62, abstract number.

Cell-matrix interactions in lung disease and regeneration

Symposium
Chairs: R. Chambers (London, United Kingdom), S. Meiners (München, Germany)
Aims: This special session aims to highlight some of the key cutting-edge concepts regarding cell-matrix interactions across the spectrum of respiratory disease and regenerative medicine that were presented during the 2018 Lung Science Conference (LSC) in Estoril. Cells sense and functionally respond to their physical three-dimensional environment by translating extracellular matrix (ECM) interactions and mechanical forces and deformations into biochemical signals. Molecular defects that interrupt or alter mechanical sensing and the subsequent cell signalling events can perturb normal cellular function, thereby potentially contributing to a diverse range of diseases, including those that associate with abnormal lung development, acute lung injury, pulmonary fibrosis, airway remodelling and cancer. In this session, we will review the latest developments in our understanding of the way perturbed cell-ECM interactions determine cell fate and function and can lead to respiratory disease. This session will include presentations by an exciting panel of leading investigators who are working at the forefront of respiratory science and medicine as well as two short presentations from two prize winners at the 2018 LSC.

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Human lung scaffolds to model lung disease and tissue regeneration D. Wagner (Lund, Sweden)
Matrix dysfunction and the aging lung H. Schiller (Munich, Germany)
Laser-capture microdissection, mass spectrometry and immunohistochemistry reveal pathological alterations in the extracellular matrix of transplanted lungs C. Mueller (Lund, Sweden)
Progress towards human lung regeneration in end-stage respiratory failure: studying human lung development in vitro using organoid cultures of human embryonic lung stem cells M. Nikolic (Cambridge (Cambridgeshire), United Kingdom)
Stem cell renewal and the matrix T. Maher (St. Albans (Hertfordshire), United Kingdom)