G. Caramori (Ferrara, Italy), P. Kirkham (Wolverhampton , United Kingdom)
Pharmacological effect of lysozyme for COPD and bronchial asthma with sputum: A randomized, placebo-controlled, cross-over study
H. Ohbayashi, Y. Setoguchi, Y. Fukuchi, K. Shibata, Y. Sakata, T. Arai (Mizunami, Shinjuku, Bunkyo, Japan)
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Repeated lipopolysaccharide stimulation causes corticosteroid insensitive inflammation in lung via phosphoinositide-3-kinase δ signaling
G. Kimura, K. Ueda, Y. Nishimoto, T. Masuko, T. Kusama, P. J. Barnes, K. Ito, Y. Kizawa (Funabashi, Japan; London, United Kingdom)
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RP6503, a novel and selective PI3K δ/gamma inhibitor, potentiates the effect of steroids in pre-clinical models of COPD
K. Routhu, B. Govindrajulu, S. Veeraraghavan, S. Viswanadha, S. Vakkalanka (Hyderabad, India; La Chaux-de-Fonds, Switzerland)
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Preclinical characterization of CPL-302-201, a novel, highly potent and selective PI3Kδ inhibitor for the treatment of inflammatory disorders
P. Gunerka, O. Musielak, B. Dymek, D. Zdzalik, M. Zagozda, M. Dziachan, M. Malczyk, A. Bujak, P. Grygielewicz, M. Skupinska, J. Hucz-Kalitowska, K. Dubiel, M. Lamparska-Przybysz, M. Wierczorek, A. Stanczak (Lomianki, Warsaw, Lodz, Poland)
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In vitro characterization of a novel inhaled PI3Kd inhibitor LAS194223
M. Calbet, M. Lehner, M. Bravo, J. Cabedo, S. Paris, S. Soria, M. Erra, M. Miralpeix (Sant Feliu del Llobregat, Spain)
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Pre-clinical evaluation of a novel and selective PI3K δ/gamma inhibitor in pulmonary fibrosis
K. Routhu, B. Govindrajulu, S. Veeraraghavan, S. Viswanadha, S. Vakkalanka (Hyderabad, India; La Chaux-de-Fonds, Switzerland)
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In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
I. Ramis, C. Carreño, A. Orellana, M. Maldonado, J. Bach, M. Miralpeix (Sant Feliu de Llobregat, Spain)
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Therapeutic potential of CPL-407-105 – Novel potent JAK/STAT pathway inhibitor for the treatment of asthma
P. Gunerka, B. Dymek, D. Zdzalik, M. Mroczkiewicz, J. Lipner, B. Stypik, A. Bujak, P. Grygielewicz, O. Musielak, M. Skupinska, J. Hucz-Kalitowska, K. Dubiel, M. Lamparska-Przybysz, M. Wieczorek, A. Stanczak (Lomianki, Lodz, Warsaw, Poland)
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The novel elastase inhibitor BAY 85-8501: First-in-man study to evaluate safety, tolerability and pharmacokinetics in healthy male subjects
J. Nagelschmitz, M. Becka, D. Kaufel, S. Schwers, F. von Nussbaum, V. Li, G. Wensing (Wuppertal, Germany)
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The novel elastase inhibitor BAY 85-8501: Bioavailability and Food effect study to evaluate pharmacokinetics of tablet formulations
J. Nagelschmitz, M. Becka, D. Kaufel, S. Schwers, G. Wensing (Wuppertal, Germany)
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The effect of JQ1/SGCBD01 upon c-Myc in human airway smooth muscle in asthma
M. Perry, A. Durham, G. Sehra, I. Adcock, F. Chung (London, United Kingdom)
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H4 receptor antagonits as a potential medication for upper airway cough syndrom
E. Kovacova, S. Gavliakova, M. Brozmanova, T. Buday, J. Plevkova (Martin, Slovakia)
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PPAR-alpha agonist (fenofibrate) therapy in exacerbation control of chronic obstructive pulmonary disease of severe stage
O. Enikeev, S. Enikeeva, N.R. Bikmetova (Ufa, Russian Federation)
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Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
S. Grundy, J. Plumb, M. Kaur, S. Lea, D. Singh (Manchester, United Kingdom)
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Translational study searching for synergy between glycopyrronium and indacaterol
M. Cazzola, L. Calzetta, A. Segreti, F. Facciolo, P. Rogliani, M. G. Matera (Rome, Naples, Italy)
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Simvastatin suppresses the activity of Th2 and Tc2 cells in atopic asthma and in COPD
J. Knobloch, Y. Yakin, B. Grensemann, S. Körber, D. Jungck, A. Koch (Bochum, Cologne, Germany)
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Biochemical and functional characterization of lysyl oxidase like 2 (LOXL2) inhibitors
R. Rajagopalan, S. Misialek, J. X. Huang, L. Hooi, H. Ramesha, J. Nicholas, J. Ramphal, K. Emayan, L. Pan, S. Yap, L. Huang, S. Seiwert, B. Buckman (Brisbane, United States Of America)
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Treatment with low-dose everolimus in patients with sporadic lymphangioleiomyomatosis (LAM)
S. Avdeev, M. Makarova, Z. Merzhoeva, A. Chuchalin (Moscow, Russian Federation)
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