LATE-BREAKING ABSTRACT: Inhibition of the ubiquitin-E3-ligase FBXW7 enhances steroid efficacy: New concept for treating steroid insensitivity
Marc Kaestle (Biberach, Germany), Marc Kaestle, David Wyatt, Paul Nicklin
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LATE-BREAKING ABSTRACT: Alveolar nitric oxide, small airway physiology and plasma biomarkers following inhaled allergen challenge in asthmatic subjects
Henning Svensson (Malmö, Sweden), Henning Svensson, Zuzana Diamant, Leif Bjermer, Ellen Tufvesson
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Airway hyperresponsiveness (AHR) of small airways assessed by impulse oscillation (IOS) in adult asthma
Hisatoshi Hijikata (Aichi, Japan), Hisatoshi Hijikata, Masaya Takemura, Norihisa Takeda, Kensuke Fukumitsu, Hiroya Ichikawa, Takamitsu Asano, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Atsushi Nakamura, Akio Niiimi
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Lung overexpression of matrix metalloproteinase-2 protects against bronchial asthma
Kentaro Fujiwara (Mie, Japan), Kentaro Fujiwara, Kentaro Urata, Atsushi Tomaru, Yoshinori Takahashi, Masahiro Onishi, Takehiro Takagi, Hiroyasu Kobayashi, Corina N. D’Alessandro Gabazza, Esteban C. Gabazza, Osamu Taguchi, Tetsu Kobayashi
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Integrins regulate eosinophil adhesion to the airway smooth muscle cells in asthma patients
Andrius Januskevicius (Kaunas, Lithuania), Andrius Januskevicius, Simona Lavinskiene, Reinoud Gosens, Deimante Hoppenot, Virginija Kalinauskaite-Zukauske, Ieva Janulaityte, Laura Tamasauskiene, Raimundas Sakalauskas, Kestutis Malakauskas
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Biomarkers of obesity associated with severe atopic asthma
Anna Konishcheva (Moscow, Russian Federation), Anna Konishcheva, Valentina Geervazieva
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Physiology of severe vs. mild-moderate U-BIOPRED cohorts interpreted using a computational model
Edward Ingenito (Cambridge, United States of America), Edward Ingenito, Jeanette Bigler, Dirk Smith, Ian Adcock, Anthony Rowe, Fan Chung, Ratko Djukanovic, Ana Sousa, Peter Sterk, Ajay Nirula
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The temporal stability of coagulation and fibrinolytic factors in patients with asthma and healthy subjects
Anne de Kievit (Amsterdam, Netherlands), Anne De Kievit, Marlous Sneeboer, Christof Majoor, Joost Meijers, Rene Lutter, Tom Van der Poll, Pieter-Willem Kamphuisen, Peter Sterk, Elisabeth Bel
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D-tryptophan influences allergic airway inflammation and Th2 immune responses
Katrin Milger (Munich, Germany), Katrin Milger, Constanze Müller, Inge Kepert, Petra Nathan, Juliano Fonseca, Kerstin Hochwind, Sabine Bartel, Oliver Eickelberg, Anton Hartmann, Philippe Schmitt-Kopplin, Susanne Krauss-Etschmann
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Antibody responses to rhinovirus and echovirus antigens in children with asthma exacerbations
Jua Iwasaki (London, United Kingdom), Jua Iwasaki, Lee Ying Chai, Siew-Kim Khoo, Joelene Bizzintino, Ingrid A. Laing, Peter N. Le Souëf, Wayne R. Thomas, Belinda J. Hales
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QGE031 (ligelizumab) is more effective than omalizumab and placebo in inhibiting allergen-induced early asthmatic response: Results from a predictive modeling study
Gail Gauvreau (Hamilton, Canada), Gail M. Gauvreau, Louis-Philippe Boulet, Richard Leigh, Donald W. Cockcroft, Beth E. Davis, Irvin Mayers, J. Mark FitzGerald, Barbro Dahlen, R.M. Watson, Joanne Milot, Veronica Swystun, Linda Hui, Ann-Sofie Lantz, Miranda Bowen, Jonathan Arm, Suzzane Maahs, Karin Meiser, Philip Lowe, Andrej Skerjanec, Christopher Carlsten, Karin Strandberg, Kieran J. Killian, Michele Laviolette, Anton Drollmann, Paul M. O’Byrne
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A PKPD mathematical model to determine efficacy of multiple doses of QGE031 (ligelizumab) vs. omalizumab and placebo in inhibiting skin responses in atopic asthmatics
Philip Lowe (Basel, Switzerland), P.J. Lowe, I. Bottoli, J. Arm, A. Skerjanec, A. Groenewegen, S. Maahs
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Serum Th2 cytokine profiles in mould sensitised adults from a large population-based cohort
Jeanette Reece (Melbourne, Australia), Jeanette Reece, Rangi Kandane-Rathnayake, Mimi Tang, Julie Simpson, Iain Feather, Melissa Southey, John Hopper, Stephen Morrison, Graham Giles, EHaydn Walters, Shyamali Dharmage, Melanie Matheson
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The capacity of human airway epithelium to regulate T cell proliferation is reduced in asthma
Irene Heijink (Groningen, Netherlands), Irene Heijink, Paul Fitch, Janneke Heimweg, Claire Wilson, Reina Matsuda, Maarten Van den Berge, Antoon Van Oosterhout, Jurgen Schwarze
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Azithromycin exhibits interferon-inducing properties in an experimental mouse model of asthma exacerbation
Mandy Menzel (Lund, Sweden), Mandy Menzel, Hamid Akbarshahi, Lena Uller
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IL-4 induced changes in the Wnt signalling of bronchial epithelial cells
Katharina Dietz (Munich, Germany), Katharina Dietz, Hoeke Baarsma, Melanie Koenigshoff, Carsten Schmidt-Weber, Kathrin Suttner
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The impact of anxiety and depression on asthma-related health outcomes: A prospective study
Anthony Yii (Singapore, Singapore), Anthony Yii, Chee Kiang Tay, Therese Lapperre, Li Leng Tan, Florence Yeoh, Mariko Koh
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