Collagen remodelling by airway smooth muscle is resistant to steroids and beta 2-agonists

Bourke J.E., Li X., Foster S.R., Wee E., Dagher H., Ziogas J., Harris T., Bonacci J.V., Stewart A.G.

Source: Eur Respir J 2011; 37: 173-182
Journal Issue: January
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Bourke J.E., Li X., Foster S.R., Wee E., Dagher H., Ziogas J., Harris T., Bonacci J.V., Stewart A.G.. Collagen remodelling by airway smooth muscle is resistant to steroids and beta 2-agonists. Eur Respir J 2011; 37: 173-182

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The effect of adenosine on VEGF release from airway smooth muscle from subjects with asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Pathophysiology of bronchial smooth muscle remodelling in asthma
Source: Eur Respir J 2010; 36: 1174-1184
Year: 2010



Involvement of the BK channels/G proteins processes in the synergistic effects between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle
Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management
Year: 2013


Endothelin-1-mediated contraction of mouse small airways is resistant to salbutamol, but sensitive to rosiglitazone
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013

Long-term effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in severe asthma
Source: International Congress 2016 – Asthma: from basic mechanisms to novel therapeutic perspectives
Year: 2016

Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Beta2-agonists but not glucocorticoids inhibit proliferation of asthmatic airway smooth muscle cells
Source: Eur Respir J 2004; 24: Suppl. 48, 251s
Year: 2004

Central role of AC6 in β2 agonist induced relaxation of human airway smooth muscle
Source: International Congress 2016 – Novel insights into the treatment of COPD
Year: 2016


Distribution of increased airway smooth muscle thickness and airway inflammation in asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Serelaxin is a potent inhibitor of airway contraction and enhances β-adrenoceptor-mediated relaxation
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Contractility of bronchial smooth muscle and changes during disease
Source: Annual Congress 2005 - Role of the bronchial smooth muscle in regulating airway disease
Year: 2005

Contribution of bronchial smooth muscle to inflammation
Source: Annual Congress 2005 - Role of the bronchial smooth muscle in regulating airway disease
Year: 2005

Fevipiprant reduces airway smooth muscle mass in asthmatics via PGD2 receptor antagonism
Source: International Congress 2017 – Novel mechanisms and treatments for asthma
Year: 2017




Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema
Source: Eur Respir J 2007; 30: 691-700
Year: 2007



A comparison of beta2-adrenoceptor desensitisation induced by olodaterol and formoterol in human lung mast cells and airway smooth muscle cells
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison
Source: Eur Respir J 2007; 30: 653-661
Year: 2007



Corticosteroids and beta2-agonists modify hyaluronic acid homeostasis in human airway smooth muscle cells in asthma and COPD
Source: Annual Congress 2009 - Translational research/biomarkers
Year: 2009

Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Treating asthma means treating airway smooth muscle cells
Source: Eur Respir J 2008; 32: 265-274
Year: 2008