A fully dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a murine model of asthma

L. Reber, F. Daubeuf, S. Gerlo, G. Haegeman, N. Frossard, K. de Bosscher (Illkirch, France; , Belgium)

Source: Annual Congress 2010 - Pre-clinical models of airways disease
Session: Pre-clinical models of airways disease
Session type: Oral Presentation
Number: 5149
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Reber, F. Daubeuf, S. Gerlo, G. Haegeman, N. Frossard, K. de Bosscher (Illkirch, France; , Belgium). A fully dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a murine model of asthma. Eur Respir J 2010; 36: Suppl. 54, 5149

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Estrogen prevents airway hyperresponsiveness in a murine model of allergic asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 433s
Year: 2006

Estrogen prevents airway inflammation and hyperresponsiveness in a murine model of acute allergic asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 360s
Year: 2007

Dissociation of the effects of a steroid on inflammation compared to airway hyperresponsiveness (AHR) in a model of asthma in conscious mice
Source: Eur Respir J 2001; 18: Suppl. 33, 30s
Year: 2001

Effects of IL-4Rα blockade on lung inflammation and airway hyperresponsiveness using Mu317RAXMu, a murine surrogate for AMG 317, in a treatment model of cockroach allergen-induced asthma in mice
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Inhaled PPAR-r agonist inhibit the airway inflammation in murine model of acute and chronic asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 24s
Year: 2007

MMP-9 deficiency reduces airway inflammation and hyperresponsiveness in a mouse model of asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

A dual role of IL-6 signalling and STAT-3 activation on airway inflammation versus airway hyperresponsiveness in a murine model of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 568s
Year: 2002

Obesity enhances allergen-induced airway inflammation in a murine model of asthma
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Activated protein C inhibits bronchial inflammation and hyperresponsiveness in a mouse model of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 618s
Year: 2002

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in the airway remodeling induced by chronic airway inflammation in guinea pigs
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

Involvement of NK1, 2 and 3 receptors on antigen-induced airway hyperresponsiveness and inflammation induced in guinea-pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 246s
Year: 2001

The PAR2-activating peptide SLIGRL inhibits airway hyper-responsiveness and eosinophilia in an acute murine model of allergic asthma
Source: Annual Congress 2004 - Animal models of asthma and chronic bronchitis and their relevance in pulmonary pharmacology
Year: 2004


The inflammation and the airway hyperresponsiveness in allergic asthma is inhibited by IL-10 dependent mechanism
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Hepatocyte growth factor attenuates airway hyperresponsiveness and airway inflammation in a murine model of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 27s
Year: 2002

Budesonide reverses IL-13–induced airway hyper-responsiveness but has little effect on β2 agonist response in human small airways
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012

B cells are crucial in the regulation of airway hyperreactivity in an experimental model of asthma
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Effect of 1,25(OH)2D3 on the airway inflammation in asthmatic rat model
Source: Eur Respir J 2005; 26: Suppl. 49, 580s
Year: 2005

Disruption of CD44 variant 6 abolished bronchial hyperresponsiveness, inflammation and mast cell myositis in a murine model of asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 217s
Year: 2006

Oral presentation: The role of mast cells, IL-13 and TRP channels in a mouse model of chemical-induced airway hyperresponsiveness
Source: Lung Science Conference 2013 - Early origins and mechanisms of chronic lung disease
Year: 2013

Oral presentation: The role of mast cells, IL-13 and TRP channels in a mouse model of chemical-induced airway hyperresponsiveness
Source: Lung Science Conference 2013 - Early origins and mechanisms of chronic lung disease
Year: 2013