Protective effect of a Protein Epitope Mimetic (PEM) CXCR4 antagonist, POL5551, in an allergic model of asthma

F. Daubeuf, B. Romagnoli, E. Chevalier, N. Frossard (Illkirch, France; Allschwil, Switzerland)

Source: Annual Congress 2010 - Models of airways disease
Session: Models of airways disease
Session type: E-Communication Session
Number: 3704
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Daubeuf, B. Romagnoli, E. Chevalier, N. Frossard (Illkirch, France; Allschwil, Switzerland). Protective effect of a Protein Epitope Mimetic (PEM) CXCR4 antagonist, POL5551, in an allergic model of asthma. Eur Respir J 2010; 36: Suppl. 54, 3704

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Protective effect of a protein epitope mimetic (PEM) CCR10 antagonist, POL7085, in an allergic model of asthma
Source: Annual Congress 2011 - Translational models of airway disease
Year: 2011


Protective effect of thrombomodulin in a murine model of allergen-induced asthma
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in the mouse
Source: Annual Congress 2013 –Novel drugs for the treatment of asthma and COPD
Year: 2013

Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459
Source: Eur Respir J 2013; 41: 46-52
Year: 2013



Alpha-7 nicotinic receptor stimulation reduces airway inflammation in a murine model of asthma
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

The effect of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild to moderate asthma
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

Anti-inflammatory effects of roflumilast N-oxide and dexamethasone in human bronchial epithelial cells stimulated with toll-like receptor agonists
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


The effect of anti-IL-33 antibody and soluble ST2 in a murine model of allergic asthma
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013

Resveratrol upregalates PTEN and inhibits MUC5AC expression in ovalbumin (OVA)-induced asthma model mice
Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action
Year: 2016

Effects of the novel toll-like receptor 7 (TLR7) agonist AZD8848 on allergen-induced responses in patients with mild asthma
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Effect of retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness
Source: International Congress 2015 – Immune aspects of asthma and other airway diseases
Year: 2015

Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice
Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Year: 2016


A novel inhaled PI3Kδ inhibitor, LAS194223 reduces allergen-induced airway inflammation in rat
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014

Late Breaking Abstract - The Role of the chemokine receptor CCR3 in House Dust Mite (HDM) induced experimental asthma
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


TLR 7/8 agonist resiquimod alleviates murine allergic asthma through IL-27 production and up regulation of B7-H1 on antigen presenting cells
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Pharmacological profile of a novel, potent and oral TRPA1 antagonist. Characterization in a preclinical model of induced cough
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

Exploring the role of Coxsackie and Adenovirus Receptor (CAR) in allergic airway inflammation
Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses
Year: 2019

The effect of the inhaled PDE4 inhibitor CHF6001 on allergen-induced inflammation in asthmatics
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

Acid sphingomyelinase deficiency improves lung function in allergen-induced asthma in mice
Source: Annual Congress 2013 –Cell biology and murine models of asthma and inflammation
Year: 2013

Cytokine-induced glucocorticoid resistance: Effect on GILZ expression and reversal by formoterol
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013