Modulatory effect of cigarette smoke on the translation of CEBPA and CEBPB mRNA in human lung fibroblasts: COPD/emphysema as a translation control disease

N. Miglino, M. Roth, M. Tamm, P. Borger (Switzerland)

Source: Annual Congress 2010 - Lung cell biology and immunology
Session: Lung cell biology and immunology
Session type: Thematic Poster Session
Number: 2402
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Miglino, M. Roth, M. Tamm, P. Borger (Switzerland). Modulatory effect of cigarette smoke on the translation of CEBPA and CEBPB mRNA in human lung fibroblasts: COPD/emphysema as a translation control disease. Eur Respir J 2010; 36: Suppl. 54, 2402

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Repeated exposure to cigarette smoke extract (CSE) in primary human lung fibroblasts – effects on proliferation rate
Source: Eur Respir J 2006; 28: Suppl. 50, 635s
Year: 2006

Cigarette smoke down-regulates the expression of β-catenin in primary human lung fibroblasts
Source: Annual Congress 2011 - Lung cell biology
Year: 2011

Cigarette smoke inhibits lung fibroblast proliferation by translational mechanisms
Source: Eur Respir J 2012; 39: 705-711
Year: 2012



Cigarette smoke extract (CSE) induces clusterin expression in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 105s
Year: 2004

miRNA expression in the lung in response to cigarette smoke
Source: Annual Congress 2009 - miRNAs in inflammation and disease
Year: 2009


Cigarette smoke extract induces ER stress in human lung fibroblasts from COPD patients and healthy subjects
Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease
Year: 2019

Specific knockdown of versican 1 ameliorated the impairment of elastin deposit in pulmonary fibroblasts co-cultured with cigarette smoke
Source: Annual Congress 2013 –The vulnerable patient and ageing cells
Year: 2013

Cigarette smoke alters the EZH2/DAB2IP expression in bronchial epithelial cells. A risk factor for lung cancer in COPD patients
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

Acute effect of cigarette smoke on human bronchial epithelial cell metabolome is reversible by UPF1
Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Year: 2013


Effect of whole cigarette smoke exposure and CCSP on MUC5AC mucin production in primary cultures of human bronchial epithelial cells at air-liquid interface of COPD, smokers and control patients
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Murine lung airway fibroblasts drive fibrosis through STAT4 signaling after cigarette smoke exposure
Source: Annual Congress 2012 - The smoking gun in COPD biology
Year: 2012

Comparison of the gene expression profile in lung fibroblasts from patients with emphysema and changes in gene expression induced by cigarette smoke extract (CSE)
Source: Eur Respir J 2006; 28: Suppl. 50, 585s
Year: 2006

Reduced airway expression of cytoprotective CC10 in COPD patients and mice exposed to cigarette smoke
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

A protective effect of FAM13A in human bronchial epithelial cells upon exposure to cigarette smoke
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

Therapeutic neutralization of the matrikine PGP suppresses the development of lung emphysema in cigarette smoke exposed mice
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Cigarette smoke significantly reduces proliferation and modulates the expression levels of CEBPα and CEBPβ in cultured human lung fibroblasts
Source: Annual Congress 2008 - Basic science in asthma and COPD II
Year: 2008


Cigarette smoke in mice, rats and guinea-pigs: value to the study of pathogenic factors involved in COPD
Source: Annual Congress 2005 - PG11 - Experimental models for COPD and asthma
Year: 2005

Dynamic global gene expression shows mitigation of the effects of cigarette smoke extract by antioxidants in airway cells
Source: Annual Congress 2008 - Novel trends in functional genomics and molecular pathology of neoplastic and non-neoplastic lung diseases
Year: 2008


In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice
Source: Eur Respir J 2011; 38: 932-938
Year: 2011



COPD fibroblasts are more responsive to cigarette smoke exposure
Source: Annual Congress 2009 - Mechanisms of pulmonary inflammation and fibrosis
Year: 2009