Selective NF-κB inhibition of human dendritic cell differentiation induces T cell unpolarization by repressing T-bet/GATA-3 ratio

L. Zhou, X. Gu, M. Zhang, X. Ji, M. Huang, K. Yin (Nanjing, China)

Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Session: Mechanisms and modulation of allergic inflammation in the lung
Session type: Thematic Poster Session
Number: 1367
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Zhou, X. Gu, M. Zhang, X. Ji, M. Huang, K. Yin (Nanjing, China). Selective NF-κB inhibition of human dendritic cell differentiation induces T cell unpolarization by repressing T-bet/GATA-3 ratio. Eur Respir J 2010; 36: Suppl. 54, 1367

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Budesonide induces cell apoptosis, increases foxp3 expression, and reduces icos expression in T cell subpopulations of asthmatics
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009

Mast cell activation leads to migration of T-cells in vitro
Source: Annual Congress 2007 - Mechanisms of inflammation in asthma and rhinitis - from cell cultures to patients
Year: 2007


Targeted NF-κB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking model
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009


Selective inhibition of COX-2 by celecoxib exerts negative effects on endothelial progenitor cell proliferation and stimulates apoptosis in vitro
Source: Eur Respir J 2005; 26: Suppl. 49, 368s
Year: 2005

ROG negatively regulating the expression of T cell cytokines through modulation on ICOS
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012


Effects of dendritic cells overexpressing Serrate1 on the polarization of CD4+CD25+ T cells and the production of inhibitory cytokines in vitro
Source: Eur Respir J 2005; 26: Suppl. 49, 25s
Year: 2005

High-level expression of programmed death ligand-1 by dendritic cells promotes the expression of Foxp3 in CD4+ CD25+regulatory T cells
Source: Annual Congress 2008 - Novel therapeutic approaches and immunological mechanisms in airway cell pathobiology
Year: 2008

Surfactant decreases LPS-dependent CD4+ T cell stimulation by dendritic cells
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009

Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses tumor-specific T cell immunity
Source: Annual Congress 2012 - New aspects of lung cancer biology
Year: 2012

The role of NFATc1 in T cell responses during the development of NSCLC
Source: International Congress 2017 – Basic research in lung cancer: a scientific potpourri from genetic alterations to immune cells
Year: 2017


The relationship between Notch expression and T cell differentiation in COPD
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


A549 cell promotes the proliferation and migration of fibroblast through FXR pathway
Source: International Congress 2019 – Biology of lung cancer
Year: 2019

Effects of triptolide on T lymphocyte activation and transcription of interleukin-5 gene and its mechanisms
Source: Eur Respir J 2003; 22: Suppl. 45, 483s
Year: 2003

Depletion of STAT6 suppresses lung cancer progression through regulating M2-macrophage polarization
Source: International Congress 2018 – Lung cancer: from the bench to the bedside
Year: 2018

The expression of PD-L1 on the lung cancer cell and its role in T cell anergy
Source: Eur Respir J 2007; 30: Suppl. 51, 289s
Year: 2007

5-Hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of human dendritic cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Hypoxia induces IL-1β and TNF-α expressionin of U937 cells involving PKCα/RAF-1/MAPK/NF-κB pathway
Source: Eur Respir J 2005; 26: Suppl. 49, 102s
Year: 2005

Human myeloid lung dendritic cells are strong inducers of T cell proliferation compared to plasmacytoid lung dendritic cells
Source: Annual Congress 2005 - Basic mechanisms in asthma and COPD: new insights
Year: 2005


KPNB1-mediated PD-L1 nuclear translocation promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signalling pathway
Source: Virtual Congress 2020 – Biological mechanisms of lung cancer
Year: 2020