Secretion of wound-induced TGF-beta1 and TGF-beta2 enhance airway epithelial repair via HB-EGF and TGF-alpha

J. Ito, N. Harada, O. Nagashima, F. Makino, H. Yagita, K. Okumura, R. Atsuta, H. Akiba, K. Takahashi (Tokyo, Japan)

Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Session: Mechanisms and modulation of allergic inflammation in the lung
Session type: Thematic Poster Session
Number: 1366
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Ito, N. Harada, O. Nagashima, F. Makino, H. Yagita, K. Okumura, R. Atsuta, H. Akiba, K. Takahashi (Tokyo, Japan). Secretion of wound-induced TGF-beta1 and TGF-beta2 enhance airway epithelial repair via HB-EGF and TGF-alpha. Eur Respir J 2010; 36: Suppl. 54, 1366

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-?1 in airway fibroblasts in asthma
Source: Eur Respir J 2014; 43: 464-473
Year: 2013



Interleukin-8 stimulates human airway epithelial cell proliferation through EGFR transactivation
Source: Eur Respir J 2003; 22: Suppl. 45, 561s
Year: 2003

TNF-α and TGF-β1 synergistically upregulate the expression of endothelin-1 in airway epithelial cell
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009

Glucocorticoids enhance CCL20 release in bronchial epithelial cells in a metalloprotease-dependent manner
Source: Annual Congress 2011 - Epithelial cell biology
Year: 2011


CCL5 (RANTES) inhibits TGF-β1-induced collagen production in human bronchial epithelial cells by action of Smad protein
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

Activation of PAR-2 enhances ICAM-1 expression and IL-8 release in airway epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 571s
Year: 2002

Transforming growth factor-β induces collagen synthesis without inducing IL-8 production in mesothelial cells
Source: Eur Respir J 2003; 22: 197-202
Year: 2003



VEGF induces ECM synthesis and fibroblast activity in human lung fibroblasts
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Thrombin stimulates mucin secretion from airway epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 570s
Year: 2002

Chemokine profiles of A549 human alveolar epithelial cells that underwent epithelial-mesenchymal transition by TGF-b and/or TNF-a
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012


Wnt11 inhibits effects of transforming growth factor-beta1 (TGFbeta1) on lung epithelial phenotype
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013


Increased extracellular pressure stimulates interleukin-8 secretion by human bronchial epithelial cells
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010

Epidermal growth factor receptor (EGFR) overexpression in human bronchial epithelial cells amplifies IL-8 release provoked by cigarette smoke and bacterial surrogates
Source: Eur Respir J 2005; 26: Suppl. 49, 441s
Year: 2005

Dimethylfumarate reduces growth factor- and cytokine-induced IL-6 release from human lung fibroblasts: role of (NF)-κB
Source: Annual Congress 2008 - Airway cell biology and immunology
Year: 2008

Synergistic effect of cysteinyl-leukotrienes and epidermal growth factor on human lung fibroblast mitogenesis
Source: Eur Respir J 2005; 26: Suppl. 49, 340s
Year: 2005

Leptin stimulates CXCL2 and CXCL8 production in airway epithelial cells
Source: Annual Congress 2009 - Lung cell biology and immunology
Year: 2009


Rhinovirus uses EGFR signaling to coordinate IL-8 and ICAM-1 expression in bronchial epithelial cells
Source: Annual Congress 2008 - Best of lung epithelial cells 2008
Year: 2008


Expression of amphiregulin regulates airway remodeling
Source: Annual Congress 2008 - Understanding allergic airway inflammation with the help of animal models
Year: 2008

In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
Source: Annual Congress 2012 - Diffuse parenchymal lung disease I
Year: 2012

Fibroblast growth factor 23 and Klotho contribute to airway inflammation
Source: Eur Respir J, 52 (1) 1800236; 10.1183/13993003.00236-2018
Year: 2018