Muscarinic receptor selectivity of aclidinium bromide and glycopyrrolate in vitro

I. Ramos, J. Beleta, D. Vilella, M. Gómez-Angelats, M. Aparici, E. Calama, C. Carcasona, M. Miralpeix, A. Gavaldà (Barcelona, Spain)

Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Session: Regulation of airway hyperresponsiveness and bronchodilators
Session type: Thematic Poster Session
Number: 1234
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
I. Ramos, J. Beleta, D. Vilella, M. Gómez-Angelats, M. Aparici, E. Calama, C. Carcasona, M. Miralpeix, A. Gavaldà (Barcelona, Spain). Muscarinic receptor selectivity of aclidinium bromide and glycopyrrolate in vitro. Eur Respir J 2010; 36: Suppl. 54, 1234

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Rate of onset of action of aclidinium bromide, a novel, long-acting, muscarinic antagonist
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


Safety and pharmacokinetics of aclidinium bromide, a novel, long-acting muscarinic antagonist, in renally impaired subjects
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


Efficacy and safety of aclidinium bromide, a novel long-acting muscarinic antagonist, in patients with moderate to severe COPD
Source: Annual Congress 2009 - New bronchodilators
Year: 2009

An oral selective M3 cholinergic receptor antagonist in COPD
Source: Eur Respir J 2006 Oct 01;28(4):772-780
Year: 2006



Aclidinium bromide, a novel muscarinic receptor antagonist combining long residence at M3 receptors and rapid plasma clearance
Source: Annual Congress 2007 - New drugs for COPD
Year: 2007


Synergistic effects between glycopyrronium bromide and indacaterol on a muscarinic agonist-induced contraction in airway smooth muscle
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Synergistic bronchoprotective activity of the long-acting beta 2-agonist olodaterol with tiotropium (long-acting M3 antagonist) and ciclesonide (inhaled steroid) on the ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs
Source: Annual Congress 2011 - Understanding disease and drug mechanisms
Year: 2011


Indacaterol acetate, glycopyrronium bromide, and mometasone furoate: effect on neuronal inflammation and acetylcholine release
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021


A potential role for dissociation rate from the M3 muscarinic receptor in the onset of action of NVA237 and tiotropium
Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators
Year: 2010

In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407
Source: Eur Respir J 2007; 30: Suppl. 51, 26s
Year: 2007

Rapid plasma hydrolysis of aclidinium bromide, a novel long-acting anticholinergic drug
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008


Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

PF-00610355 – an inhaled β2 adrenoceptor agonist with superior potency and duration of action (DoA) to salmeterol in the conscious dog model of bronchoconstriction
Source: Annual Congress 2009 - Models of chronic airways disease and therapy
Year: 2009

Bronchodilator/bronchoprotective effects of aclidinium bromide, a novel long-acting anticholinergic: a phase I study
Source: Annual Congress 2007 - Mechanisms and new treatments of COPD
Year: 2007


ACCLaim/COPD II: efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist in COPD patients, a phase III study
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


Pharmacokinetics of PF-00610355, a novel inhaled long-acting β2-adrenoreceptor agonist
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


The efficacy and safety of long-acting muscarinic antagonist treatment for COPD
Source: International Congress 2019 – Advances in chronic obstructive pulmonary disease and asthma
Year: 2019


Interaction between tiotropium  bromide and olodaterol in small human airways
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Efficacy and tolerability of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients
Source: Annual Congress 2007 - Mechanisms and new treatments of COPD
Year: 2007