Lung fibroblasts regulate the urokinase-type plasminogen activator receptor (uPAR) expression of alveolar epithelial cells and endothelial cells

K. Takahashi, K. Kobayashi, M. Mitsui, T. Odaka, H. Nakamura, T. Matsuoka (Ami, Japan)

Source: Annual Congress 2006 - Mechanisms of acute lung injury and of fibrosis
Session: Mechanisms of acute lung injury and of fibrosis
Session type: Thematic Poster Session
Number: 2341
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Takahashi, K. Kobayashi, M. Mitsui, T. Odaka, H. Nakamura, T. Matsuoka (Ami, Japan). Lung fibroblasts regulate the urokinase-type plasminogen activator receptor (uPAR) expression of alveolar epithelial cells and endothelial cells. Eur Respir J 2006; 28: Suppl. 50, 2341

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Human lung microvascular endothelial cells (HMVEC-L) angiogenic activity is inhibited by stable plasminogen activator inhibitor-1 (PAI-1) mutants via urokinase-dependent pathway
Source: Annual Congress 2004 - Lung development and cancer
Year: 2004


Pro-urokinase up-regulates the expression of urokinase type plasminogen activator (u-PA) in human pulmonary arterial endothelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 143s
Year: 2007

Plasminogen activator inhibitor-1 (PAI-1) mutations of extended half-life time inhibit angiogenic properties of human lung microvascular endothelial cells (HMVEC-L)
Source: Eur Respir J 2003; 22: Suppl. 45, 225s
Year: 2003

Regulation of plasminogen activator activity by inflammatory mediators in lung epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 343s
Year: 2005

The mechanism of plasminogen activator inhibitor type-1 (PAI-1) Cys mutants inhibitory activity towards lung capillaries endothelial cells (HMVEC-L)
Source: Eur Respir J 2005; 26: Suppl. 49, 93s
Year: 2005

The regulation of plasminogen activator inhibitor-1 (PAI-1) production with dexamethasone by human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 343s
Year: 2005

The effect of prostaglandin (PG) E2 and its receptor antagonists on urokinase-type plasminogen activator (uPA) production by human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 811s
Year: 2006

Influence of prostaglandin E2 on cell surface urokinase-type plasminogen activator expression and activity in lung adenocarcinoma cell line
Source: Eur Respir J 2005; 26: Suppl. 49, 457s
Year: 2005

Proapoptotic and anti-proliferative effect of the stable plasminogen activator inhibitor type 1 (PAI-1) mutant on the lung cancer and endothelial cells
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Upregulation of the gene encoding the urokinase-type plasminogen activator (uPA) in respiratory muscles of COPD patients
Source: Annual Congress 2004 - Skeletal muscle in respiratory disease
Year: 2004


Urokinase plasminogen activator receptor variants drive distinct phenotypes in the bronchial epithelium
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015

SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor growth and lung metastasis formation probably through the reduction of tumor angiogenesis
Source: Annual Congress 2011 - Progress in pathology of lung cancer
Year: 2011

Plasminogen activator inhibitor (PAI)-1 is expressed in human eosinopils stimulated by TGF-β
Source: Eur Respir J 2006; 28: Suppl. 50, 590s
Year: 2006

Plasminogen activator inhibitor type 1 (PAI-1) is a negative regulator of lung cancer cells growth due to its anti-proteinase activity
Source: Annual Congress 2008 - Novel targets in the molecular pathology of lung cancer and COPD
Year: 2008


Urokinase type plasminogen activator improves airway inflammation and mucin expression in a murine asthma model
Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2010

Urokinase plasminogen activation receptor (uPAR) levels correlate with bronchial epithelial barrier integrity
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014


Vascular endothelial growth factor (VEGF) isoform expression in primary human cultured alveolar epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 84s
Year: 2003

Effects of hypoxia on VEGF and VEGF-R expression by human alveolar epithelial (ATII) and human pulmonary microvascular endothelial (HMVEC-l) cells
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008

Caveolin-1 regulation of thrombin signalling in endothelial cells
Source: Annual Congress 2009 - Acute lung injury: biological mechanisms
Year: 2009


Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
Source: Eur Respir J 2016; 47:1568-1571
Year: 2016