COX-1 driven biosynthesis of PGD2 during activation of human mast cells prevents formation of other prostanoids Source: Virtual Congress 2020 – Novel molecular markers and targets for asthma phenotypes Year: 2020
Genetic regulation of expression of leukotriene A4 hydrolase Source: ERJ Open Res 2016 Year: 2016
Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells Source: Eur Respir J 2004; 24: Suppl. 48, 29s Year: 2004
IL-8 and COX-2 expression is regulated through cPLA2-derived arachidonate metabolites in human lung cells Source: Annual Congress 2003 - Intracellular signalling and regulation of cytokine production Year: 2003
PGD2 biosynthesis in several human mast cell models is catalyzed by cycloxygenase-1 Source: Annual Congress 2011 - Mechanisms of allergic inflammation of the airways Year: 2011
Fevipiprant inhibits eosinophil activation induced by multiple metabolites of prostaglandin D2 Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses Year: 2019
Effect of endothelin on DNA synthesis in human bronchial eipthelial cells: role of MAPK cascade Source: Eur Respir J 2001; 18: Suppl. 33, 476s Year: 2001
GB001 potently inhibits PGD2 metabolite-induced DP2-mediated cell signaling and eosinophil activation Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms Year: 2020
Inhibition of eosinophil migration by montelukast, a cysteinyl leukotriene receptor antagonist, through down regulation of plasmin activity Source: Eur Respir J 2004; 24: Suppl. 48, 36s Year: 2004
Differential effects of pharmacological leukotriene pathway modulators in a human lung tissue explant model Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms Year: 2020
Direct relationship between inhibition of leukotriene release in lung and free plasma concentration of a LTC4 synthase inhibitor in a rat model Source: International Congress 2015 – New models for treating airway diseases Year: 2015
Quantitative assessment of cysteinyl leukotrienes in human sputum during the allergen-induced asthmatic response and the effect of GSK2190915, a 5-lipoxygenase activating protein (FLAP) inhibitor Source: Annual Congress 2011 - Diagnosis and treatment of inflammatory respiratory diseases Year: 2011
The novel phosphodiesterase 4 inhibitor CI-1044 inhibits in vitro LPS-induced TNFα production in whole blood of COPD patients Source: Eur Respir J 2001; 18: Suppl. 33, 34s Year: 2001
Liver-X-receptor agonists, but not dexamethasone, inhibit leukotriene production from human white blood cells pretreated with GM-CSF and activated with fMLP Source: Annual Congress 2007 - New treatments for asthma and COPD - experimental evidence Year: 2007
MTOR regulates TGFß-induced collagen synthesis via increased glycine biosynthesis Source: ERS Lung Science Conference 2018 Year: 2018
Role of the JAK/STAT pathway in activation of the xanthine dehydrogenase/oxidase in lung microvascular endothelial cells exposure to hypoxia Source: Eur Respir J 2007; 30: Suppl. 51, 145s Year: 2007
Dual inhibition of thromboxane synthase and 5-lipoxygenase, potentially significant mechanism for the treatment of asthma Source: Eur Respir J 2001; 18: Suppl. 33, 264s Year: 2001
Effect of PDE4 inhibitors on MAPK activation and IL-8 production on A549 cells following the induction of oxidative stress Source: Eur Respir J 2005; 26: Suppl. 49, 99s Year: 2005
The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells Source: Eur Respir J 2003; 22: Suppl. 45, 100s Year: 2003
Cigarette smoke altered the expression of choline acetyl transferase and muscarinic receptors promoting the LTB4 release from human bronchial epithelial cells Source: Annual Congress 2008 - Airway cell biology Year: 2008