Cloned Th cells confer airway obstruction upon antigen challenge in the absence of IgE antibody – a model for nonatopic bronchoconstriction

A. Mori, T. Otomo, N. Kitamura, O. Kaminuma (Sagamihara, Japan)

Source: Annual Congress 2009 - Animal models of airways inflammation
Session: Animal models of airways inflammation
Session type: E-Communication Session
Number: 4734
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Mori, T. Otomo, N. Kitamura, O. Kaminuma (Sagamihara, Japan). Cloned Th cells confer airway obstruction upon antigen challenge in the absence of IgE antibody – a model for nonatopic bronchoconstriction. Eur Respir J 2009; 34: Suppl. 53, 4734

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Induction of allergic bronchial hyperreactivity in DA-rats despite low-level eosinophilia in airways and lack of specific IgE antibodies
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Intratracheal instillation of antigen-specific IgG ameliorated murine bronchial asthma via reduction of antigen presentation of airway dendritic cells
Source: Annual Congress 2008 - Understanding allergic airway inflammation with the help of animal models
Year: 2008


A monoclonal antibody to IL-1B attenuates the late asthmatic response to antigen challenge in patients with mild asthma
Source: Annual Congress 2006 - Novel treatments for asthma
Year: 2006


Immunomodulation of the allergic airway inflammation by allergen DNA targeted receptors for the Fc region on dendritic cells in mice sensitized/challenged by OVA allergen
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


CD4 + T-helper cells engineered to produce IL-10 reverse allergen-induced airway hyperreactivity and inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 432s
Year: 2001

Down regulation of ICOS and CTLA 4 on allergic asthmatic T cells upon Derp1 stimulation
Source: Annual Congress 2006 - Novel mechanisms in asthmatic inflammation
Year: 2006

The development of an airway hyperresponsiveness (AHR) depends on mast cells following sensitization without adjuvant
Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Year: 2006


Anti-IL-5 antibody reduces the increase of CD34+ eosinophils in a mouse model of airway allergic eosinophilia
Source: Eur Respir J 2002; 20: Suppl. 38, 28s
Year: 2002

In situ proliferation of bronchial T-cells in asthma
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009

Naturally occurring CD4+ CD25+ FoxP3+ Treg cells are related to the absence of antigen induced airway obstruction in a guinea pig asthma model
Source: Annual Congress 2011 - Asthma: basic science and clinical studies
Year: 2011


The vaccination with DNA encoding T cell epitope on the Der p inhibited allergic responses in mice
Source: Eur Respir J 2002; 20: Suppl. 38, 28s
Year: 2002

Dissociation between airway responsiveness to methacholine and responsiveness to antigen
Source: Eur Respir J 2002; 19: 76-83
Year: 2002



Der p 2-derived peptide abrogates HDM-induced allergic asthma in mouse and humanized model
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

TNF-α negatively modulates allergen-induced airway hyperresponsiveness through γδ T cells
Source: Eur Respir J 2002; 20: Suppl. 38, 27s
Year: 2002

The response of airway epithelial cells to Aspergillus fumigatus allergen protease exposure
Source: Annual Congress 2010 - Proteases and the matrix
Year: 2010

IL-10-producing CD4+ T cells are essential for the development of airway hyperresponsiveness
Source: Annual Congress 2004 - Modulation of the allergic response in animal models
Year: 2004


DNA vaccine encoding both PD-L1 and Der p 2 was more effective than DNA vaccine encoding only Der p 2 in suppressing airway inflammation in a murine model of allergic airway disease
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


CAT-354, an IL-13-neutralising human monoclonal antibody, inhibits airways hyperresponsiveness and eosinophilia in a cynomolgus monkey model of allergen challenge
Source: Eur Respir J 2005; 26: Suppl. 49, 232s
Year: 2005

Total IgE and Der p 1 (D1) specific IgE in induced sputum (IS) in patients with allergic and non-allergic asthma
Source: International Congress 2018 – Biomarkers for evaluating asthma
Year: 2018


LSC - 2017 - Evaluation the effect of bronchoconstriction on airway epithelial cells responses in asthma
Source: International Congress 2017 – Asthma and allergy: from the bench to the bedside
Year: 2017