Corticosteroids reduce pro-inflammatory cytokine expression in airway smooth muscle cells via upregulation of MAPK phosphatase-1 and inhibition of p38 MAPK signalling Source: Eur Respir J 2005; 26: Suppl. 49, 713s Year: 2005
Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment Year: 2011
Involvement of NFkB activation and c-JUN phosphorylation in bronchial epithelial cells by CD-40-CD40L pathway Source: Eur Respir J 2002; 20: Suppl. 38, 573s Year: 2002
Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases Year: 2010
Cigarette smoke upregulates IL-8/CXCL8 expression by augmenting mRNA stability via p38 MAPK/MK2 signalling in normal human pulmonary cells Source: Annual Congress 2012 - Basic and translational studies in COPD Year: 2012
TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts Source: Eur Respir J 2004; 24: Suppl. 48, 718s Year: 2004
Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression Source: Eur Respir J 2003; 22: Suppl. 45, 10s Year: 2003
Thrombin induces stomatin-like protein 2 (STOML2) expression and IL-8/CXCL8 release by ROCK, JNK, and PEA3 pathways in human lung epithelial cells Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms Year: 2020
Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2 , via activation of p38 mitogen-activated protein kinase Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms Year: 2005
Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring Year: 2007
Autocrine secretion of bradykinin prevents alveolar type II cells from mechanical stretch-induced apoptosis by activation – role of PI3K and Akt Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury Year: 2008
GATA-3 phosphorylation by p38 MAP kinase plays a critical role in regulating Th2 cytokine gene expression Source: Eur Respir J 2003; 22: Suppl. 45, 386s Year: 2003
6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway Source: Virtual Congress 2020 – Translational therapeutic advances Year: 2020
G-protein mediated EGFR transactivation induces mucin production Source: Annual Congress 2003 - Cellular and molecular mechanisms in epithelium injury and repair Year: 2003
Crystalline silica activates redox-sensitive signalling pathways and up-regulates cyclooxygenase-2 Source: Eur Respir J 2004; 24: Suppl. 48, 107s Year: 2004
Analysis of cytokine signaling pathway JAK-STAT through their activation in patients with asthma Source: Annual Congress 2008 - Novel mechanisms and targets of molecular pulmonary pathology Year: 2008
Intermittent hypoxia activates the Interleukin (IL)-1ß and nuclear factor (NF)?B signaling pathway in primary murine macrophages Source: International Congress 2019 – Insights into the pathophysiology of sleep-disordered breathing Year: 2019
In addition to mTOR and JAK/STAT, NLRP3 inflammasome is another key pathway activated in sarcoidosis Source: Eur Respir J, 55 (3) 2000149; 10.1183/13993003.00149-2020 Year: 2020
Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD Source: International Congress 2016 – Studies in airway cell biology Year: 2016
N-Acetylcysteine inhibits eotaxin and MCP-1 release in human airway smooth muscle cells in vitro through the inhibition of ROS production, resulting in a decrease of p38 MAP kinase activation Source: Eur Respir J 2002; 20: Suppl. 38, 170s Year: 2002