PK/PD, safety and tolerability of a human anti-IL-1B monoclonal antibody (ACZ885) in healthy subjects

J. Bonner, P. Lloyd, P. Lowe, G. Golor, R. Woessner, S. Pascoe (Horsham, United Kingdom; Berlin, Germany; Basel, Switzerland)

Source: Annual Congress 2006 - Novel treatments for asthma
Session: Novel treatments for asthma
Session type: Oral Presentation
Number: 748
Disease area: Airway diseases

Congress or journal article abstractSlide presentation

Rating: 5
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Bonner, P. Lloyd, P. Lowe, G. Golor, R. Woessner, S. Pascoe (Horsham, United Kingdom; Berlin, Germany; Basel, Switzerland). PK/PD, safety and tolerability of a human anti-IL-1B monoclonal antibody (ACZ885) in healthy subjects. Eur Respir J 2006; 28: Suppl. 50, 748

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Population pharmacokinetics of tralokinumab, an investigational anti-IL-13 monoclonal antibody, in asthmatic and healthy adults
Source: Annual Congress 2012 - Clinical aspects and treatment of asthma and allergic respiratory diseases
Year: 2012

Safety profile and clinical activity of multiple subcutaneous (SC) doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in subjects with asthma
Source: Annual Congress 2010 - Novel anti-inflammatory agents for airway disease
Year: 2010


Long-term safety and tolerability of omalizumab, an anti-IgE monoclonal antibody, in patients with severe allergic asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 48s
Year: 2005

Phase 2, mutlicenter, double-blind study of CNTO 148, a human monoclonal anti-TNF α antibody, in symptomatic patients with severe persistent asthma
Source: Annual Congress 2007 - Clinical trial: new biological approaches to respiratory diseases
Year: 2007


Treatment with omalizumab (rhuMAb-E25), a monoclonal anti-IgE antibody induces effective changes in subjects with allergic asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 37s
Year: 2001

Preclinical development of an IL-13 neutralising antibody, CAT-354, for the treatment of human asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 367s
Year: 2005

A double-blind, placebo-controlled, study to assess the pharmacokinetics, safety and tolerability of multiple ascending intravenous doses of CAT 354, a recombinant human anti-IL13 antibody, in subjects with moderate asthma
Source: Annual Congress 2008 - New treatments for asthma
Year: 2008

Efficacy of an anti-IL13 monoclonal antibody, lebrikizumab, in adults with inadequately controlled asthma is enhanced in those with high periostin levels
Source: Annual Congress 2011 - New treatments for airway disease
Year: 2011

Relationship between omalizumab pharmacokinetics (PK), IgE pharmacodynamics (PD) and clinical symptoms in patients with severe persistent allergic asthma
Source: Annual Congress 2008 - Improving asthma and anti-allergic therapy
Year: 2008


Patient characteristics that can predict response to omalizumab an (anti-IgE antibody) for achieving better control of asthmatic patients
Source: Annual Congress 2012 - Asthma treatment: efficacy and safety
Year: 2012


Safety, tolerability and pharmacokinetics of AZD9668, an oral neutrophil elastase inhibitor, in healthy subjects and patients with COPD
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
Source: Eur Respir J 2013; 41: 330-338
Year: 2013



The effects of efalizumab, an anti-CD11a monoclonal antibody (hu1124), on allergen-induced airway inflammation in atopic asthmatic subjects
Source: Eur Respir J 2001; 18: Suppl. 33, 350s
Year: 2001

Tolerability assessment of a recombinant humanized monoclonal anti-IgE antibody (omalizumab) as a treatment for seasonal allergic rhinitis
Source: Eur Respir J 2002; 20: Suppl. 38, 116s
Year: 2002

Novel inhaled delivery of anti-IL-13 mAb (Fab fragment): preclinical efficacy in allergic asthma
Source: International Congress 2017 – Evolution or revolution in the treatment of asthma and allergies
Year: 2017

Safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of GSK573719 inhalation powder in healthy subjects
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

A multiple ascending subcutaneous (SC) dose study of MEDI-563, a humanized anti-IL-5Rα monoclonal antibody, in adult asthmatics
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Phase 1 study of a novel, prolonged-action anti-IL-5 monoclonal antibody in asthma
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



MEMP1972A, an anti-M1 prime monoclonal antibody, reduces serum IgE in healthy and allergic rhinitis subjects
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012

Long-term asthma control with omalizumab, an anti-IgE monoclonal antibody, in patients with severe allergic asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 47s
Year: 2005