In COPD moxifloxacin enhances th1-immune response in the presence of bacterial endotoxin by inducing IL-2 expression

S. Chikosi, D. Jungck, K. Schild, K. Urban, J. Knobloch, A. Koch (Cologne, Germany)

Source: Annual Congress 2009 - Inflammatory cells and cytokines
Session: Inflammatory cells and cytokines
Session type: Thematic Poster Session
Number: 2150
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Chikosi, D. Jungck, K. Schild, K. Urban, J. Knobloch, A. Koch (Cologne, Germany). In COPD moxifloxacin enhances th1-immune response in the presence of bacterial endotoxin by inducing IL-2 expression. Eur Respir J 2009; 34: Suppl. 53, 2150

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
TLR-4 downregulation in COPD impairs cytokine release from monocytes and Th1-lymphocytes in response to bacterial endotoxin
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Exaggerated IL-6 responses to LPS after viral airway infection in mice is mediated by endogenous TNF-a production
Source: Annual Congress 2007 - Immunological function in viral and nonviral pathogens
Year: 2007



The IL-2-dependent Th1 response to bacterial infections is suppressed in COPD
Source: Annual Congress 2012 - Immunologic mechanisms in COPD and asthma
Year: 2012

Effects of HSP70 induction on IL-6 production from murine alveolar epithelial cells pre-treated with endotoxine after subsequent endotoxin challenge
Source: Eur Respir J 2005; 26: Suppl. 49, 346s
Year: 2005

LPS-induced TLR4 expression and cytokine release is impaired in monocytes and T-lymphocytes of COPD patients
Source: Annual Congress 2008 - Novel targets in the molecular pathology of lung cancer and COPD
Year: 2008

Role of endogenous interleukin-17 in early neutrophil recruitment after endotoxin exposure in mouse airways in vivo
Source: Eur Respir J 2003; 22: Suppl. 45, 566s
Year: 2003

Dexamethasone exhibits dual response to expression and production of eotaxin in the lung fibroblast
Source: Eur Respir J 2005; 26: Suppl. 49, 551s
Year: 2005

Ionomycin stimulates a synergistic effect of IL-8 and induced sputum on PMN chemotaxis during COPD
Source: Annual Congress 2010 - COPD and asthma: models and human studies
Year: 2010


IL-10 produced by CD4+ T cells is essential for the development of airway hyperresponsiveness via suppression of endogenous IL-12
Source: Eur Respir J 2005; 26: Suppl. 49, 24s
Year: 2005

In vitro study of the inflammatory response, mediated by interleukin-8, in mesothelial cells stimulated with doxycycline
Source: Eur Respir J 2007; 30: Suppl. 51, 103s
Year: 2007

Muramyldipeptide synergistically increases interleukin-8 secretion from bronchial epithelial cells in a cell culture model of gramnegative infection
Source: Eur Respir J 2006; 28: Suppl. 50, 340s
Year: 2006

GM-CSF and CSF-1 co-regulate lung inflammation and ERMP12+ progenitor recruitment during immune responses to LPS in vivo
Source: Eur Respir J 2006; 28: Suppl. 50, 300s
Year: 2006

The PBMC of severe asthmatics showed enhanced candida antigen induced IL-5, IL-13 and TARC production and this enhancement was inhibited by dendric cells deprition
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009

Fevipiprant is superior to montelukast in suppressing type 2 cytokine production from mast cell stimulated human Th2 cells
Source: International Congress 2019 – Precision meets immunology in treatment of airway diseases
Year: 2019




Pseudomonas aeruginosa modulates the pulmonary immune response by affecting the IL17 / IL22 axis
Source: International Congress 2018 – Mechanisms of respiratory infection
Year: 2018

Differential gene expression and cytokine production from neutrophils in asthma phenotypes
Source: Eur Respir J 2010; 35: 522-531
Year: 2010



Bacterial killing is enhanced after exogenous administration of lysozyme in the lungs
Source: Eur Respir J 2001; 18: Suppl. 33, 9s
Year: 2001

Effect of QVAR® on inflammatory cells and cytokine gene expression in early and late sputum samples in asthmatics
Source: Eur Respir J 2002; 20: Suppl. 38, 502s
Year: 2002

IL-6 and IL-8 production induced by Pseudomonas aeruginosa flagellin in human bronchial epithelial cells.
Source: International Congress 2017 – Infection and exacerbation science
Year: 2017


Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001