Hypoxia induced pulmonary hypertension – the role of dimethylarginine dimethylaminohydrolase 1 (DDAH-1) in acute and sustained hypoxic vasoconstriction

A. Gaber, N. Sommer, N. Huang, A. Ghofrani, R. Schermuly, W. Seeger, F. Grimminger, J. Cooke, N. Weissmann (Giessen, Germany; Stanford, United States Of America)

Source: Annual Congress 2009 - Pulmonary circulation
Session: Pulmonary circulation
Session type: E-Communication Session
Number: 1880
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Gaber, N. Sommer, N. Huang, A. Ghofrani, R. Schermuly, W. Seeger, F. Grimminger, J. Cooke, N. Weissmann (Giessen, Germany; Stanford, United States Of America). Hypoxia induced pulmonary hypertension – the role of dimethylarginine dimethylaminohydrolase 1 (DDAH-1) in acute and sustained hypoxic vasoconstriction. Eur Respir J 2009; 34: Suppl. 53, 1880

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Attenuated expression and activity of dimethylarginine dimethylaminohydrolase may play a key role in monocrotaline-induced pulmonary hypertension by accumulation of endogenous NOS inhibitors in rats
Source: Annual Congress 2006 - Signalisation in the pulmonary vasculature: new pathways and wrong signals
Year: 2006


Increased alveolar epithelial expression of dimethylarginine dimethylaminohydrolase 2 in idiopathic pulmonary fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 823s
Year: 2006

Asymmetric dimethylarginine (ADMA) to monitor treatments of pulmonary hypertension
Source: International Congress 2019 – Endpoints and risk assessment of pulmonary arterial hypertension
Year: 2019



Lipopolysaccharide attenuates endothelial barrier function through a pp60Src mediated inhibition of dimethylaminohydrolase (DDAH)
Source: Annual Congress 2011 - Barrier functions in sepsis and acute lung injury
Year: 2011

High-altitude pulmonary hypertension
Source: Eur Respir Rev 2009; 18: 13-17
Year: 2009


Expression of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) in pulmonary arteries of patients with severe COPD
Source: Annual Congress 2003 - Pathophysiology of the pulmonary circulation
Year: 2003


Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction
Source: Eur Respir J 2003; 21: 19-24
Year: 2003



Correlation of inhaled nitric-oxide induced reduction of pulmonary artery pressure and vascular changes
Source: Eur Respir J 2002; 20: 52-58
Year: 2002



Shroom expression is attenuated in hypoxia-induced pulmonary hypertension
Source: Eur Respir J 2006; 28: Suppl. 50, 147s
Year: 2006

Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
Source: Eur Respir J 2010; 36: 323
Year: 2010



Biomarkers in pulmonary hypertension
Source: Eur Respir J 2008; 32: 503-512
Year: 2008



Cirrhosis ameliorates monocrotaline-induced pulmonary hypertension in rats
Source: Eur Respir J 2009; 34: 731
Year: 2009



Effect of the Asp298 variant of endothelial nitric oxide synthase on acute pulmonary vasodilator testing response in idiopathic pulmonary arterial hypertension
Source: Eur Respir J 2006; 28: Suppl. 50, 547s
Year: 2006

The effect of bosentan in occlusive pulmonary hypertension in rats – Role of oxidative and nitrative stress attenuation
Source: Annual Congress 2010 - Pulmonary vascular diseases
Year: 2010

Effects of hypobaric hypoxia on circulating microRNA expression and hypoxic pulmonary vasoconstriction
Source: International Congress 2016 – Pulmonary hypertension: novel insights
Year: 2016


TRAM-34 ameliorates hypoxia-induced pulmonary arterial hypertension in rats
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013


Role of the nitric oxide-asymmetric dimethylarginine-dimethylarginine dimethylaminohydrolase (NO-ADMA-DDAH) axis in TGF-β mediated epithelial-mesenchymal transition
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015


Effects of the NO donor molsidomine on prostacyclin synthase gene expression in rats with chronic hypoxic pulmonary hypertension
Source: Eur Respir J 2001; 18: Suppl. 33, 414s
Year: 2001

Role of hypoxia inducible factor 1alpha (HIF-1alpha) in delayed myocardial preconditioning induced by intermittent hypoxia (IH) in the rat
Source: Annual Congress 2006 - Taormina 4th ERS Lung Science Conference "hypoxia in lung biology and disease"
Year: 2006


Atrial natriuretic peptide plasma concentration (ANP) and pulmonary hemodynamics (HEMO) after acute nitric oxide inhalation (NO) in patients with connective tissue disease and pulmonary artery hypertension (CTDPH)
Source: Eur Respir J 2005; 26: Suppl. 49, 561s
Year: 2005