Increased shedding of low density lipoprotein receptor-related protein-1 (LRP-1) in patients with acute respiratory distress syndrome (ARDS) prevents cellular clearance of matrix metalloproteinase-2 (MMP-2) and correlates with disease severity

M. Wygrecka, E. Jablonska, A. Günther, K. T. Preissner, P. Markart (Giessen, Germany)

Source: Annual Congress 2009 - Acute lung injury: biological mechanisms
Session: Acute lung injury: biological mechanisms
Session type: Oral Presentation
Number: 1813
Disease area: Respiratory critical care

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Wygrecka, E. Jablonska, A. Günther, K. T. Preissner, P. Markart (Giessen, Germany). Increased shedding of low density lipoprotein receptor-related protein-1 (LRP-1) in patients with acute respiratory distress syndrome (ARDS) prevents cellular clearance of matrix metalloproteinase-2 (MMP-2) and correlates with disease severity. Eur Respir J 2009; 34: Suppl. 53, 1813

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Regulation, cell-specific expression and metabolism of factor VII activating protease (FSAP) in lungs from patients with acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2006; 28: Suppl. 50, 823s
Year: 2006

Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in acute respiratory distress syndrome (ARDS)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

Relationship between circulating serpina 3g, activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, 2 with chronic obstructive pulmonary disease severity
Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD
Year: 2018

Frequency and significance of vascular endothelial growth factor (VEGF) 936 C/T polymorphism in acute respiratory distress syndrome (ARDS)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease
Year: 2003


Circulating matrix metalloproteinase-9 (MMP-9) is associated with the extension of lung disease in patients with active tuberculosis
Source: Eur Respir J 2004; 24: Suppl. 48, 35s
Year: 2004

Elevated serum B cell activating factor belonging to the TNF family (BAFF) in interstitial lung diseases associated with collagen vascular disease
Source: Annual Congress 2012 - Diffuse parenchymal lung disease: clinical profiles and collagen vascular disease
Year: 2012

Increased intraalveolar level of soluble endothelial protein C receptor in patients with interstitial lung disease
Source: Eur Respir J 2004; 24: Suppl. 48, 319s
Year: 2004

Variable tissue expression of transferrin receptors: relevance to acute respiratory distress syndrome
Source: Eur Respir J 2003; 22: 335-341
Year: 2003



Serum levels of vascular endothelial growth factor (VEGF) are elevated in patients with acute exacerbated COPD
Source: Eur Respir J 2005; 26: Suppl. 49, 350s
Year: 2005

Circulating fibronectin to C-reactive protein ratio and mortality: a biomarker in COPD?
Source: Eur Respir J 2008; 32: 1451-1457
Year: 2008



Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients
Source: Eur Respir J 2005; 25: 885-890
Year: 2005



Increased METEORIN-LIKE (ML) expression promotes lung inflammation in asthma.
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

High mobility group box protein-1 suppresses efferocytosis in ARDS
Source: Annual Congress 2010 - Novel markers of lung injury
Year: 2010


Inhibition of granulocyte activation by surfactant in a 2-yr-old female with meningococcus-induced ARDS
Source: Eur Respir J 2002; 19: 776-779
Year: 2002



Regulation of vascular endothelial growth factor expression in a mouse model of acute respiratory distress syndrome (ARDS)
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Increased concentration of matrix metalloproteinase-9 in serum of COPD patients
Source: Eur Respir J 2005; 26: Suppl. 49, 54s
Year: 2005

Human macrophage elastase (MMP-12) expression in human emphysematous lungs: role in extracellular matrix remodelling in chronic obstructive pulmonary diseases (COPD)
Source: Eur Respir J 2001; 18: Suppl. 33, 501s
Year: 2001

High mobility group box protein 1 (HMGB1) production in highly vascularized alveolar lesions causes acute exacerbation in idiopathic pulmonary fibrosis
Source: Annual Congress 2005 - Progresses in lung fibrosis
Year: 2005


Alpha1-antitrypsin (α1-AT) and secretory leukocyte protease inhibitor (SLPI) in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in critically ill infants
Source: Annual Congress 2008 - Respiratory disorders in paediatric intensive care unit
Year: 2008