A phase 1 multiple dose safety and pharmacokinetics study of AIR645, an inhaled IL-4rα 2-MOE GAPMER oligonucleotide

M. Hodges, E. Castelloe, A. Chen, R. Geary, J. Karras, R. Larouche, D. Shapiro, B. Yeung, R. Yu, S. Gregory (San Diego, Carslbad, United States Of America; Montréal, Canada)

Source: Annual Congress 2009 - New drugs for airways disease
Session: New drugs for airways disease
Session type: Oral Presentation
Number: 1800
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Hodges, E. Castelloe, A. Chen, R. Geary, J. Karras, R. Larouche, D. Shapiro, B. Yeung, R. Yu, S. Gregory (San Diego, Carslbad, United States Of America; Montréal, Canada). A phase 1 multiple dose safety and pharmacokinetics study of AIR645, an inhaled IL-4rα 2-MOE GAPMER oligonucleotide. Eur Respir J 2009; 34: Suppl. 53, 1800

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
An open-label trial to investigate the dose delivery and tolerability of inhaled dry powder mannitol (IDPM) using low output and high output OrbitalÔ inhalers across defined flow rates in healthy volunteers
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012


Dose escalation study in healthy male subjects to investigate safety, tolerability and systemic exposure of orally inhaled single-doses of AP301
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Safety, tolerability and pharmacokinetics (PK) of AZD8154 (a selective PI3K?d inhibitor) after single ascending inhaled doses in healthy volunteers
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD7594 after single and multiple ascending inhaled doses in healthy Japanese males
Source: International Congress 2017 – COPD management
Year: 2017

A phase 1, single-center, open-label, dose-rising clinical trial to evaluate the pharmacokinetics, safety and tolerability of treprostinil inhalation powder (TreT) in healthy normal volunteers
Source: International Congress 2019 – Pulmonary hypertension: clinical
Year: 2019


The safety, tolerability, pharmacodynamics and pharmacokinetics of inhaled fluticasone furoate (FF) and vilanterol (VI) are unaffected by administration in combination
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I
Year: 2011

Fevipiprant (QAW039) demonstrates safety, tolerability and consistent PK at high oral doses
Source: International Congress 2017 – Asthma: mechanisms and treatment
Year: 2017


A randomised double-blind, study to determine the efficacy & safety of a once-daily inhaled β2 adrenoreceptor agonist, PF-00610355 in asthmatic patients
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


A long-term (2 years) efficacy and safety study of doxofylline in the treatment of asthma
Source: International Congress 2019 – Clinical studies of asthma treatments
Year: 2019

INTEGRIS-IPF: a 12-week, Phase 2a study evaluating the safety, tolerability and pharmacokinetics of PLN-74809 in participants with IPF
Source: Virtual Congress 2020 – News on diagnosis and therapy of idiopathic pulmonary fibrosis
Year: 2020


A double-blind, placebo-controlled, study to assess the pharmacokinetics, safety and tolerability of multiple ascending intravenous doses of CAT 354, a recombinant human anti-IL13 antibody, in subjects with moderate asthma
Source: Annual Congress 2008 - New treatments for asthma
Year: 2008

Safety and tolerability of the novel very long acting β2-agonist Carmoterol given as a 2μg qd dose; 8 days comparison with formoterol and placebo in patients with persistent asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 665s
Year: 2006

Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Safety, tolerability and pharmacokinetics (PK) of repeated doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in healthy adults
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Comparison of the pharmacokinetic, pharmacodynamic, and safety profiles of three different formulations of intravenous epoprostenol sodium
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


A comparative study of the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of salmeterol HFA and CFC MDI inhalers in healthy subjects
Source: Eur Respir J 2004; 24: Suppl. 48, 582s
Year: 2004

Efficacy and safety of ralinepag, a novel oral IP agonist, in PAH patients on mono or dual background therapy: results from a phase 2 randomised, parallel group, placebo-controlled trial
Source: Eur Respir J, 54 (4) 1901030; 10.1183/13993003.01030-2019
Year: 2019



Dry powder inhaled ribavirin in healthy volunteers:  safety, tolerability, lung and systemic pharmacokinetics
Source: International Congress 2017 – From microbiology to clinical work
Year: 2017


A randomized, crossover study to examine the pharmacodynamics and safety of a new antimuscarinic (TD-4208) in COPD
Source: Annual Congress 2012 - Trials in COPD: novel treatments and insights
Year: 2012


A randomised, 4-way crossover study to examine the lung pharmacodynamic effects of single inhaled doses of tiotropium (18 μg), salmeterol (50 μg), tiotropium (18 μg) and salmeterol (50 μg) and placebo using whole body plethysmography in healthy subjects
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics I
Year: 2010