Smoking has potential to initiate basement membrane disruption and epithelial mesenchymal transition in COPD

S. S. Sohal, D. Reid, A. Soltani, C. Ward, S. Weston, H. Muller, R. Wood-Baker, H. Walters (Hobart, Australia; Newcastle Upon Tyne, United Kingdom)

Source: Annual Congress 2009 - Pathology and immunology of COPD
Session: Pathology and immunology of COPD
Session type: Oral Presentation
Number: 1603
Disease area: Airway diseases

Congress or journal article abstractSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. S. Sohal, D. Reid, A. Soltani, C. Ward, S. Weston, H. Muller, R. Wood-Baker, H. Walters (Hobart, Australia; Newcastle Upon Tyne, United Kingdom). Smoking has potential to initiate basement membrane disruption and epithelial mesenchymal transition in COPD. Eur Respir J 2009; 34: Suppl. 53, 1603

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Vascular and basement membrane remodelling in smokers and COPD
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Epithelial fibroblast triggering and interactions in pulmonary fibrosis
Source: Eur Respir Rev 2008; 17: 123-129
Year: 2008



The role of epithelial to mesenchymal transition (EMT) in airway remodelling after human lung transplantation
Source: Annual Congress 2008 - Vascular and interstitial remodelling in chronic lung disease: therapeutic interventions on the horizon
Year: 2008

The injury extension to the epithelial cell/epithelial basement membrane unity (EC-EBM) as the major pathogenetic determinant of lung architectural remodelling in IIP: a paradigmatic change
Source: Eur Respir J 2004; 24: Suppl. 48, 557s
Year: 2004

Epithelial to mesenchymal transition in basal progenitor epithelial cells cultured from smokers and COPD patients
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015


Normal development of the bronchial epithelial reticular basement membrane (rbm)
Source: Annual Congress 2009 - New data on respiratory function - from experimental approaches to man
Year: 2009

Cigarette smoke impairs airway epithelial barrier function and cell–cell contact recovery
Source: Eur Respir J 2012; 39: 419-428
Year: 2012



Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition
Source: Eur Respir J 2015; 45: 1258-1272
Year: 2015



Altered composition of airway basement membranes in COPD
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

COPD-related epithelial inflammation drives EMT in primary epithelial ALI-cultures
Source: International Congress 2018 – COPD: immune regulation and therapeutic targets
Year: 2018


Epithelial Pten controls acute lung injury and fibrosis by regulating intercellular junctional integrity and EMT
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012

Mechanistic target of rapamycin enhances fibrosis in lung by promoting epithelial mesenchymal transition
Source: International Congress 2019 – Intercellular communication in tissue remodelling of chronic lung diseases
Year: 2019



Epithelial mesenchymal transition (EMT) related changes in small airways of smokers and patients with COPD
Source: Virtual Congress 2021 – Pathogenic progress in airway diseases
Year: 2021


Hypoxia-induced EMT in primary human small airway epithelium is controlled by extracellular matrix interactions
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


Downregulation of lysosome-associated membrane protein-2A accelerates cigarette smoke extract-induced aging and apoptosis in human bronchial epithelial cells
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
Source: Eur Respir Rev 2014; 23: 118-130
Year: 2014



TGFβ-induced epithelial to mesenchymal transition (EMT) as a model of COPD
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016

Basement membrane, a specialized extracellular matrix, shapes endothelial function in IPAH
Source: Virtual Congress 2020 – Experimental approaches to pulmonary hypertension
Year: 2020


Noneosinophilic asthma in children: relation with airway remodelling
Source: Eur Respir J 2011; 38: 575-583
Year: 2011