The CXCL12/SDF-1, CXCR4, CXCR7 axis in experimental hypoxic pulmonary hypertension

N. Gambaryan, F. Perros, A. Lombet, M. Mazmanian, M. Humbert (Clamart, France)

Source: Annual Congress 2009 - Pathobiology of pulmonary hypertension
Session: Pathobiology of pulmonary hypertension
Session type: Oral Presentation
Number: 1587
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Gambaryan, F. Perros, A. Lombet, M. Mazmanian, M. Humbert (Clamart, France). The CXCL12/SDF-1, CXCR4, CXCR7 axis in experimental hypoxic pulmonary hypertension. Eur Respir J 2009; 34: Suppl. 53, 1587

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease
Source: Eur Respir J 2012; 39: 1415-1424
Year: 2012



Expression of angiogenic growth factors and stromal cell derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCL12 – CXCR4) biological axis in idiopathic pulmonary fibrosis: a lung tissue study
Source: Annual Congress 2008 - New insights into the pathogenesis of idiopathic pulmonary fibrosis and sarcoidosis
Year: 2008


Fractalkine and its receptor (CX3CR1) in primary pulmonary hypertension (PPH)
Source: Eur Respir J 2001; 18: Suppl. 33, 2s
Year: 2001

CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis
Source: Eur Respir J 2009; 34: 676
Year: 2009



Targeting CCR2 and CCR5 to inhibit macrophage/pulmonary artery smooth muscle cells cross-talk in pulmonary hypertension
Source: International Congress 2018 – Experimental research in pulmonary hypertension
Year: 2018

The effects of AMD3100, a CXCR4 antagonist, on the bleomycin-induced pulmonary fibrosis
Source: Annual Congress 2009 - A wide spectrum of idiopathic pulmonary fibrosis
Year: 2009

Ang-1/BMPR2 signaling and the expressions of MCP-1 and ICAM in over circulation-induced experimental pulmonary hypertension
Source: Eur Respir J 2004; 24: Suppl. 48, 533s
Year: 2004

Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21
Source: Eur Respir J 2007; 29: 1082-1093
Year: 2007



T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis
Source: Eur Respir J 2011; 38: 1136-1144
Year: 2011



Differential expression of stromal cell derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCL12 – CXCR4) biological axis between idiopathic pulmonary fibrosis and interstitial pneumonia associated with collagen vascular disease: a bronchoalveolar la
Source: Annual Congress 2008 - Interstitial lung disease in systemic and vascular disorders
Year: 2008

A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation
Source: Eur Respir J 2008; 31: 783-789
Year: 2008



Endothelin-a receptor antagonists reduce eNOS gene expression in rats with chronic hypoxic pulmonary hypertension
Source: Eur Respir J 2003; 22: Suppl. 45, 271s
Year: 2003

RAGE-dependent VCAM-1 expression in the pulmonary endothelium mediates IL-33 induced asthma pathogenesis
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017


TrkB expression is altered in hypoxia-induced pulmonary hypertension
Source: Eur Respir J 2007; 30: Suppl. 51, 606s
Year: 2007

The role of chemokine receptors in acute lung allograft rejection
Source: Eur Respir J 2010; 35: 167-175
Year: 2010



Neutralization of CXCL12 reverses established pulmonary hypertension in the sugen-hypoxia rat model
Source: International Congress 2017 – Experimental PH
Year: 2017

Hypoxia-induced increase in NO production and eNOS expression by murine pulmonary microvascular endothelial cells
Source: Annual Congress 2006 - Pulmonary circulation: inflammation and remodelling
Year: 2006


Role of anti-proliferative therapy in PAH
Source: Research Seminar 2008 - The Pulmonary Circulation: Scleroderma-Related Pulmonary Arterial Hypertension
Year: 2008


Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension
Source: Eur Respir J 2016; 48: 1137-1149
Year: 2016



The interleukin 13 receptor system is altered in pulmonary arterial hypertension
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006