LATE-BREAKING ABSTRACT: Non-invasive measurement of respiratory impedance in conscious rats utilising impulse oscillometry

C. C. K. Klein, J. T. Thomas, N. M. Mieskes, M. H. Hoffmann, H. J. S. Smith (Bad Langensalza, Berlin, Germany)

Source: Annual Congress 2009 - Lung function testing: between spirometry and structured light plethysmography
Session: Lung function testing: between spirometry and structured light plethysmography
Session type: Oral Presentation
Number: 343
Disease area: Airway diseases

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Citations should be made in the following way:
C. C. K. Klein, J. T. Thomas, N. M. Mieskes, M. H. Hoffmann, H. J. S. Smith (Bad Langensalza, Berlin, Germany). LATE-BREAKING ABSTRACT: Non-invasive measurement of respiratory impedance in conscious rats utilising impulse oscillometry. Eur Respir J 2009; 34: Suppl. 53, 343

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Member's Comments

KLEIN Carmen Claudia - 14.09.2009 13:17
IOS in rodents
Dear Dr. Rodriguez, I am so soory for my late replly, however I did not check the comments yesterday. 1.) We took 2 measurements in each condition, in bronchial reaction 3 to 5. The results were calculated as the mean of two measurements. 2.) There could be several reasons for missing Fres: a.) Fres is to find above 40 Hz. b.) The use of face mask in adapting the technical system to the animals. Similar results were found in various other animal species, like calves and pigs as well. Petra Reinhold and I myself tried to remove face mask influences from our measurements using an algorithm, provided by Hans-Juergen Smith. It worked successfully, see our publications. However, it means a lot of additional work, to recalculate each measurement. So we do not use this feature routinously. It is possible for us to use the results without resonant frequency. c.) We have to make a compromise between the time used for calculation of results and the influences of natural breathing on the results in the lower frequency range. It might be, that not all information of capacitive signal response were detected. 3.) We just tried to measure awake mice. They are not so easy to hadle like rats! Mice chew the soft foamy material inside of the mask. Our work is going on to replace this material by an other one less attractive to mice. We took some measurements in anesthetised mice, however I am not so sure if the system will reach its limitation or not. Fo more technical information, please contact Hans-Juergen Smith from Care Fusion company, present in the exhibition of this congress. Thank you and best regards! Carmen Klein

KLEIN Carmen Claudia - 14.09.2009 12:59
Test message
Just a test

RODRIGUEZ REYNA Maria Elena - 13.09.2009 13:02
Number of measurements peformed in each condition & resonant frequency pattern
Hi, I'm Dr. Rodriguez. I have 3 questions: 1.How many IOS measurements were done in each condition? and how many were taking for the results? 2. Can you explain again the reason why the Fres didn't crosses zero. 3. Is this IOS device for mice available in the market? Thanks,
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