Source: Annual Congress 2008 - Genetics, immunology and microbiology of tuberculosis
Disease area: Respiratory infections



Rating:

Share or cite this content

Citations should be made in the following way:
R. Hörster, D. Kirsten, C. Jafari, M. Ernst, A. Strassburg, U. Greinert, C. Lange (Borstel, Germany). Interferon gamma production by bronchoalveolar lavage fluid- and peripheral blood mononuclear cells in response mycobacterial antigens in patients with sarcoidosis. Eur Respir J 2008; 32: Suppl. 52, 4519

Member's Comments

Robert Hoerster - 08.10.2008 08:36
diagnosis of sarcoidosis
We made the diagnosis of sarcoidosis, when clinical and histopathological and radiographical symptoms were compatible with sarcoidosis. We excluded contact with TB by anamnesis, so that there is a remote chance that these patients, as well as the controls had actually contact to TB without knowing it.

Robert Hoerster - 08.10.2008 08:28
at M.Veltkamp
We explained the large number of positive ELISPOT results in the control with the fact that these patients partially come from high incidence backgrounds for TB. Allthough by anamnesis no history of TB and no known contact to TB-patients was known.

Marcel Veltkamp - 07.10.2008 15:59
postive t-spot in controls
Dear author, how do you explain the large number of positive ELISPOTs for TB antigens in patients without tuberculosis or sarcoidosis. Are these false positive? Thank you, M.Veltkamp, The Netherlands

Paul Kelly - 07.10.2008 09:56
P Kelly
What was the basis of the diagnosis of sarcoidosis ? How certain can you be that these patients never had exposure / primary infection with TB in the past ? Do you think the results support the possibility of any role for mycobacteria in sarcoidosis ?

Related content which might interest you: Correlation between T-cell activation markers on lymphocytes from peripheral blood and bronchoalveolar lavage fluid in sarcoidosis patients Source: Eur Respir J 2003; 22: Suppl. 45, 226s Year: 2003 Surface activation molecules and intracellular cytokines in bronchoalveolar lavage (BAL) and blood CD3+ cells in advanced sarcoidosis Source: Eur Respir J 2002; 20: Suppl. 38, 350s Year: 2002 Phenotypic analysis of lymphocytes in bronchoalveolar lavage fluid and peripheral blood from patients with chronic inflammatory lung diseases Source: Eur Respir J 2004; 24: Suppl. 48, 534s Year: 2004 Interferon gamma (IFNgamma) decreases apoptosis rate of antigen primed T helper lymphocytes from bronchoalveolar lavage (BAL) Source: Annual Congress 2013 –Diffuse parenchymal lung disease I Year: 2013 Perforin expression and lymphocytes adhesion molecules in patients with pulmonary sarcoidosis Source: Annual Congress 2005 - Progresses in granolomatous lung disease Year: 2005 Comparison of cytotoxic markers expression on the surface of lymphocytes in BAL fluid and peripheral blood samples from patients with pulmonary sarcoidosis Source: Eur Respir J 2004; 24: Suppl. 48, 322s Year: 2004 T regulatory cells in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and controls Source: Annual Congress 2007 - Noninvasive evaluation of airway diseases Year: 2007 Non-compartmentalisation of inflammatory cytokines in bronchoalveolar lavage T cells of stable lung transplant patients Source: Eur Respir J 2005; 26: Suppl. 49, 176s Year: 2005 Activation markers of lymphocytes in bronchoalveolar lavage fluid of different sarcoidosis stages Source: Eur Respir J 2003; 22: Suppl. 45, 265s Year: 2003 T-cell cytokine pattern in bronchoalveolar lavage fluid of patients affected by different stages of pulmonary sarcoidosis Source: Eur Respir J 2002; 20: Suppl. 38, 173s Year: 2002 B1 and B2 lymphocytes in peripheral blood and bronchoalveolar lavage fluid of patients with COPD Source: International Congress 2017 – Translational studies of lung disease Year: 2017 Shifts of T4/T8 T-lymphocytes from bronchoalveolar lavage fluid and peripheral blood by clinical grade in pulmonary TB patients Source: Eur Respir J 2002; 20: Suppl. 38, 556s Year: 2002 Bronchoalveolar lavage and peripheral blood NK cells in idiopathic interstitial pneumonias Source: Annual Congress 2009 - Pathogenesis of pulmonary fibrosis Year: 2009 Oligoclonal CD8 T lymphocytes accumulates in bronchoalveolar lavage of familial pulmonary alveolar microlithiasis patients Source: Eur Respir J 2006; 28: Suppl. 50, 550s Year: 2006 Rapid diagnosis of smear negative pulmonary tuberculosis by enumeration of MTB-specific mononuclear cells from the bronchoalveolar lavage (BAL) Source: Annual Congress 2006 - Immunology of tuberculosis and diagnosis of tuberculosis infection Year: 2006 Investigation of cellularity and the cytokines profile of bronchoalveolar lavage in sarcoidosis Source: Eur Respir J 2003; 22: Suppl. 45, 255s Year: 2003 Th1/Th2 and Tc1/Tc2 profiles in bronchoalveolar lavage and sputum induction in pulmonary sarcoidosis Source: Eur Respir J 2001; 18: Suppl. 33, 107s Year: 2001 Reduced expression of PPAR-alpha in bronchoalveolar lavage CD4+ T cells of sarcoidosis patients Source: Annual Congress 2011 - T-cell subsets Year: 2011 Evaluation of bronchoalveolar cells in pulmonary paracoccidioidomycosis Source: Eur Respir J 2003 Dec 01;22(6):895-899 Year: 2003 Inflammatory and regulatory cytokine IL-6 in plasma and BAL fluid of patients with pulmonary sarcoidosis Source: Annual Congress 2009 - Bronchoalveolar lavage and phenotyping in diffuse parenchymal lung disease Year: 2009