PGD2 induces constriction of the peripheral guinea pig lung via the TP receptor

A. Hagfjärd, A. K. Larsson, M. Adner, S. E. Dahlén (Stockholm, Lund, Sweden)

Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Session: Novel experimental approaches to understanding asthma and COPD
Session type: Thematic Poster Session
Number: 3649
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Hagfjärd, A. K. Larsson, M. Adner, S. E. Dahlén (Stockholm, Lund, Sweden). PGD2 induces constriction of the peripheral guinea pig lung via the TP receptor. Eur Respir J 2008; 32: Suppl. 52, 3649

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Bronchoconstriction induced by prostaglandin D2 (PGD2) in guinea pig lung is enhanced by selective COX-2 inhibition
Source: Eur Respir J 2006; 28: Suppl. 50, 759s
Year: 2006

The effects of PGD2 and DK-PGD2 on features of airway remodeling in human airway epithelial cells and guinea pig lung slices
Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma
Year: 2020


Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Year: 2007


Endogenous PGE2 contributes to antigen-induced contractions of guinea pig trachea
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011


Antagonism by reproterol of adenosine-mediated tension responses in isolated guinea pig trachea
Source: Eur Respir J 2003; 22: Suppl. 45, 106s
Year: 2003

A novel TRPA1 antagonist inhibits ovalbumin-induced bronchoconstriction in guinea pig models
Source: International Congress 2019 – Airway inflammation: pharmacological mechanisms and novel targets
Year: 2019

Different patterns of mast cell activation and smooth muscle contractions by MRGPRX2 agonist and antigen in guinea pig trachea
Source: Virtual Congress 2020 – New insight into the pathogenesis of chronic lung diseases: asthma, COPD and others
Year: 2020


Effects of neurokinins on nNOS expression in bronchial epithelial and inflammatory cells in airways of guinea pigs
Source: Eur Respir J 2005; 26: Suppl. 49, 340s
Year: 2005

H2S excites guinea pig bronchus via TRPV1 activation
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in the airway remodeling induced by chronic airway inflammation in guinea pigs
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

The β-adrenoceptor antagonist propranolol induced Ca2+ mobilisation and enhanced contractile responses in guinea pig airways, in vitro
Source: Eur Respir J 2002; 20: Suppl. 38, 190s
Year: 2002

Modulation of antigen- and serotonin-induced airway contractions in rat precision cut lung slices by prostaglandin E2
Source: Eur Respir J 2007; 30: Suppl. 51, 714s
Year: 2007

The mediators of allergen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung (IPL) are closely similar to those in asthmatics
Source: Eur Respir J 2003; 22: Suppl. 45, 104s
Year: 2003

Insulin acutely potentiates M3 muscarinic receptor function in rat and human airway smooth muscle
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017

Spontaneous relaxation in guinea pig airway smooth muscle is not regulated by leukotrienes but by prostanoids
Source: Annual Congress 2008 - Respiratory pathophysiology from cell and animal research
Year: 2008


Alpha-1L, but not alpha-1H, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo
Source: Eur Respir J 2001; 18: Suppl. 33, 104s
Year: 2001

Zileuton abolishes an indomethacin-insensitive tone that develops in EFS contracted guinea pig tracheal smooth muscle
Source: Eur Respir J 2003; 22: Suppl. 45, 105s
Year: 2003

The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Effect of thromboxane A2(TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001

Interactions between the β2 adrenoceptor and the COX enzyme system during relaxation in guinea pig trachea
Source: Annual Congress 2007 - Recent advances in our understanding of the mechanisms of asthma treatment
Year: 2007