LPS-induced TLR4 expression and cytokine release is impaired in monocytes and T-lymphocytes of COPD patients

J. Knobloch, K. Mueller, A. Koch (Cologne, NRW, Germany)

Source: Annual Congress 2008 - Novel targets in the molecular pathology of lung cancer and COPD
Session: Novel targets in the molecular pathology of lung cancer and COPD
Session type: Oral Presentation
Number: 3005
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Knobloch, K. Mueller, A. Koch (Cologne, NRW, Germany). LPS-induced TLR4 expression and cytokine release is impaired in monocytes and T-lymphocytes of COPD patients. Eur Respir J 2008; 32: Suppl. 52, 3005

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
TLR-4 downregulation in COPD impairs cytokine release from monocytes and Th1-lymphocytes in response to bacterial endotoxin
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Rhinovirus-induced cytokine production of circulating leukocytes is reduced in severe asthma
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


The upregulation of CD-11B expression on circulating neutrophils by CXCL8 and the involvement of CXCR1 in COPD
Source: Eur Respir J 2006; 28: Suppl. 50, 749s
Year: 2006

TLR2 and TLR4 induced tolerance in alveolar macrophages; differential effect on TNFα and IL-8 release
Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Year: 2012


The relationship between PBMC secretion of IFN-alpha following TLR7 and TLR9 activation and lung function in COPD
Source: Annual Congress 2011 - Role of infection in exacerbations of COPD
Year: 2011


The PBMC of severe asthmatics showed enhanced candida antigen induced IL-5, IL-13 and TARC production and this enhancement was inhibited by dendric cells deprition
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009

Endotoxin-induced IL-17 release by murine T-lymphocytes: interactions with airway macrophages
Source: Eur Respir J 2001; 18: Suppl. 33, 408s
Year: 2001

Differential gene expression and cytokine production from neutrophils in asthma phenotypes
Source: Eur Respir J 2010; 35: 522-531
Year: 2010



Upregulated response to chemokines in oxidative metabolism of eosinophils in asthma and allergic rhinitis
Source: Eur Respir J 2003; 21: 925-931
Year: 2003



Enhanced expression of IL-18 and increased CD8+ T cells and eosinophils in the airways of asthma death
Source: Annual Congress 2010 - Mechanisms of asthma and lung inflammation
Year: 2010


Chemokinome characterization in human lung macrophages following stimulation with Th2-type cytokines IL-4 or IL-13
Source: Annual Congress 2012 - Update on neutrophil and macrophage function in COPD
Year: 2012

IL-18 and IL-12 induce inflammatory cytokines, chemokine ligand 9 (CXCL9) and T cell infiltration in pulmonary tissue
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011


Human neutrophil peptides stimulate the production of TNF alpha by alveolar macrophages from patients with sarcoidosis
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


Theophylline and budesonide downregulate production of cytokines by blood T lymphocytes of patients with COPD
Source: Virtual Congress 2021 – New insights into the airway immunology of lung disease
Year: 2021


IL-15 transpresentation in circulating progenitors of NK cells controls their differentiation potential, STAT6 activation and IL-13 production
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


Statins suppress LPS-induced proinflammatory cytokine production from human bronchial epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Increased in vitro production of IP-10/CXCL10 and MIG/CXCL9 by alveolar macrophages in sarcoidosis and EAA but not in IPF
Source: Annual Congress 2008 - Role of bronchoalveolar lavage in studying the pathophysiology of interstitial lung disease
Year: 2008

The expression of IL17RA (the common subunit of IL-17A and IL-25 receptor) on sputum macrophages in asthma patients
Source: Virtual Congress 2021 – Pearls in immunology, outcome studies and clinical trials in asthma, alpha-1 antitrypsin deficiency and COPD
Year: 2021



Elevated expression of TLR4 and HBD2 but decreased levels of IP-10 in COPD with severe exacerbation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008

Carbocisteine in vivo reduces circulating miR-21 and IL-8 in exacerbated COPD patients
Source: International Congress 2019 – COPD clinical trials: inhaled and oral therapies
Year: 2019