Chronic intermittent hypoxia accelerates atherosclerotic plaque formation in ApoE knockout mice independently of cholesterol levels

C. Arnaud, S. Cachot, N. Miguet, P. Levy (Grenoble, France)

Source: Annual Congress 2008 - Pathogenesis of obstructive sleep apnoea
Session: Pathogenesis of obstructive sleep apnoea
Session type: Oral Presentation
Number: 2773
Disease area: Sleep and breathing disorders

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Arnaud, S. Cachot, N. Miguet, P. Levy (Grenoble, France). Chronic intermittent hypoxia accelerates atherosclerotic plaque formation in ApoE knockout mice independently of cholesterol levels. Eur Respir J 2008; 32: Suppl. 52, 2773

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The effects of chronic hypoxia on pulmonary vascular reactivity in mice genetically deficient in connexin 43
Source: International Congress 2017 – Experimental PH
Year: 2017


Air space distension precedes spontaneous fibrotic remodeling and impaired cholesterol metabolism in the absence of surfactant protein C
Source: ERS Lung Science Conference 2020
Year: 2020

Reduction of endogenous acetylcholine contributes to pulmonary inflammation in a model of emphysema in mice
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

TSC1/mTOR pathway promotes hypoxia-induced pulmonary hypertension in mice
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012


Increased apolipoprotein E (ApoE) gene expression in an alveolar macrophage subpopulation of NO2-exposed rats
Source: Eur Respir J 2004; 24: Suppl. 48, 102s
Year: 2004

Beclin1 circulating levels and accelerated ageing markers in COPD
Source: International Congress 2017 – Systemic and airway biomarkers
Year: 2017

Serum osteoprotegerin expression correlates with disease progression and severity in rodent models of pulmonary arterial hypertension
Source: Annual Congress 2010 - Experimental pulmonary hypertension
Year: 2010


Loss of Bmp9 does not lead to spontaneous pulmonary hypertension, but attenuates vascular remodeling in experimental models
Source: Virtual Congress 2020 – Pathophysiology of pulmonary hypertension
Year: 2020


Pulmonary arterial hypertension phenotype in VIP knockout mice
Source: Eur Respir J 2006; 28: Suppl. 50, 546s
Year: 2006

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice
Source: Eur Respir J 2015; 46: 1451-1460
Year: 2015



Role of NFATc3 in chronic hypoxia induced pulmonary hypertension in neonatal mice
Source: Annual Congress 2010 - Pulmonary vascular diseases
Year: 2010

Disruption of Nrf2 enhances susceptibility to pulmonary fibrosis induced by bleomycin in mice
Source: Annual Congress 2011 - The ageing pulmonary interstitium
Year: 2011

Effect of eNOS gene overexpression on the vascular reactivity of isolated pulmonary arteries of chronic hypoxic rats
Source: Annual Congress 2006 - Taormina 4th ERS Lung Science Conference "hypoxia in lung biology and disease"
Year: 2006


Chronic airway inflammation alters the peripheral distribution of transferred mast cells in deficient C57BL/6-KitW-sh/W-sh mice
Source: Annual Congress 2011 - Animal models of airway inflammation
Year: 2011

Low doses of PM2.5 induces inflammation and oxidative stress with lung functional changes in mice
Source: Annual Congress 2008 - Lung, traffic and volcanoes
Year: 2008



Enhanced acute pulmonary inflammation and reduced fibrotic response in quartz-exposed p47phox-deficient mice
Source: Annual Congress 2011 - The ageing pulmonary interstitium
Year: 2011

Effect of MSC treatment on LPS-induced inflammation, emphysema and atherosclerosis in E3L mice
Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Year: 2015


Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease
Source: Eur Respir J 2007; 29: 375-378
Year: 2007



Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway
Source: Virtual Congress 2020 – New insights into sleep apnoea: from diagnosis to treatment
Year: 2020

The effect of chronic intermittent hypoxia on hepatic injury and mechanism in lean mice and mice with diet-induced obesity
Source: International Congress 2014 – Of mice and men: physiology and biology of sleep disordered breathing
Year: 2014