Performance outcomes of standardized antigen-driven IFN-g release assays for the diagnosis of active TB in a high burden setting

K. Dheda, R. van Zyl-Smit, R. Meldau, A. Whitelaw, D. Singaga, H. Chordnum, M. Isaacs, S. Isaacs, J. Huggett, R. Dawson, E. Bateman, A. Zumla (Cape Town, South Africa; London, United Kingdom)

Source: Annual Congress 2008 - Interferon-gamma release assay tests for diagnosing tuberculosis infection and disease
Session: Interferon-gamma release assay tests for diagnosing tuberculosis infection and disease
Session type: Thematic Poster Session
Number: 2529
Disease area: Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Dheda, R. van Zyl-Smit, R. Meldau, A. Whitelaw, D. Singaga, H. Chordnum, M. Isaacs, S. Isaacs, J. Huggett, R. Dawson, E. Bateman, A. Zumla (Cape Town, South Africa; London, United Kingdom). Performance outcomes of standardized antigen-driven IFN-g release assays for the diagnosis of active TB in a high burden setting. Eur Respir J 2008; 32: Suppl. 52, 2529

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Diagnostic performance of the interferon gamma release assay in elderly patients and clinical factors to support the diagnosis of active tuberculosis
Source: Annual Congress 2012 - Tuberculosis and immunologic assays
Year: 2012

Improving T-cell assays for the diagnosis of latent TB infection: potential of a diagnostic test based on IP-10
Source: Annual Congress 2008 - New methods to diagnose tuberculosis infection and disease
Year: 2008


Support of ex vivo IFN-gamma release assays in the diagnosis of tuberculosis infection in HIV/AIDS patients
Source: Annual Congress 2008 - Interferon-gamma release assay tests for diagnosing tuberculosis infection and disease
Year: 2008


IFN-gamma response on T-cell based assays in HIV patients for detection of tuberculosis infection
Source: Annual Congress 2008 - New methods to diagnose tuberculosis infection and disease
Year: 2008

Utility of antigen-specific IFN-gamma assays for monitoring of disease activity and efficacy of anti-TB treatment in HIV-/TB+ and HIV+/TB+ patients in Bulgaria
Source: Eur Respir J 2006; 28: Suppl. 50, 341s
Year: 2006

Performance of IFN-γ release assays for tuberculosis detection in immune-compromised children in a low prevalence country
Source: Annual Congress 2008 - Interferon-gamma methods for the diagnosis of tuberculosis infection and disease
Year: 2008

Poor agreement between whole-blood IFN-? assay and TST for the diagnosis of latent TB infection in children
Source: ISSN=ISSN 1810-6838, ISBN=, page=378
Year: 2007

Frequency of discordant results in interferon-γ release assay serial testing for latent tuberculosis infection in health care workers
Source: Annual Congress 2008 - Interferon-gamma release assay tests for diagnosing tuberculosis infection and disease
Year: 2008


Use of interferon-gamma release assays in diagnosis of active TB infection - Experience of a rural UK hospital
Source: Annual Congress 2013 –Tuberculosis diagnosis
Year: 2013


Screening of HIV positive TB contacts with an interferon-gamma release assay in a congregate setting in Singapore
Source: Annual Congress 2011 - Tuberculin skin tests, interferon-gamma release assays and beyond
Year: 2011

Modulation of whole-blood IGRA response in patients with latent TB infection during treatment
Source: International Congress 2018 – Tuberculosis transmission and screening strategies
Year: 2018



Indeterminate IFN-? release assay test results predict poor prognosis of active pulmonary tuberculosis
Source: International Congress 2019 – Tuberculosis: diagnosis and scores
Year: 2019


Correlation of Mycobacterium tuberculosis [not]-specific and non-specific quantitative T cell IFN-γ responses with mycobacillary load in a HIV-prevalent high burden setting
Source: Annual Congress 2012 - Prognostic indices in respiratory infections
Year: 2012


Impact of interferon-? release assay on the latent tuberculosis cascade of care: a population-based study
Source: Eur Respir J , 49 (3) 1601546; DOI: 10.1183/13993003.01546-2016
Year: 2017


Concordance between tuberculin skin testing and interferon-gamma release assays in diagnosis of latent tuberculosis infection among HIV-infected individuals
Source: Annual Congress 2012 - Tuberculosis and immunologic assays
Year: 2012

Screening for latent TB using antigen-specific IP-10 response and the effect of prednisolon
Source: Annual Congress 2012 - New developments in the immunological diagnosis of tuberculosis and latent tuberculosis infection
Year: 2012



Comparison of effector T-cell responses in patients with active TB disease compared to latent TB infection
Source: Annual Congress 2007 - New perspectives and old problems in diagnosing tuberculosis infection and disease
Year: 2007



Additional analysis of antigen-specific Interleukin-2 release does not improve the performance of IGRAs for the differentiation of different states of mycobacterium tuberculosis infection
Source: International Congress 2014 – Future frontiers in the diagnosis of Mycobacterium tuberculosis infection
Year: 2014


Comparison of whole-blood interferon-gamma release assay and tuberculin skin test results for the prediction of active tuberculosis disease in HIV-infected individuals
Source: Annual Congress 2009 - Tuberculosis and HIV co-infection
Year: 2009


Serial interferon-gamma release assays for screening and monitoring of tuberculosis infection during treatment with biologic agents
Source: Annual Congress 2013 –Tuberculosis and latent tuberculosis infection in subpopulations
Year: 2013