Close spatial relationship between CD3+ and α-actin (α-SMA)+ cells suggests T cell-myocyte/myofibroblast contact as a mechanism of airway smooth muscle (ASM) growth in asthma

D. Ramos-Barbón, R. Fraga-Iriso, N. S. Brienza, C. Montero-Martínez, H. Verea, R. Olivenstein, C. L. Lemiere, P. E. Ernst, Q. A. Hamid, J. G. Martin (A Coruña, Spain; Montreal, Canada)

Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Session: Novel mechanisms in the pathogenesis of pulmonary inflammation
Session type: Oral Presentation
Number: 1738
Disease area: Airway diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Ramos-Barbón, R. Fraga-Iriso, N. S. Brienza, C. Montero-Martínez, H. Verea, R. Olivenstein, C. L. Lemiere, P. E. Ernst, Q. A. Hamid, J. G. Martin (A Coruña, Spain; Montreal, Canada). Close spatial relationship between CD3+ and α-actin (α-SMA)+ cells suggests T cell-myocyte/myofibroblast contact as a mechanism of airway smooth muscle (ASM) growth in asthma. Eur Respir J 2008; 32: Suppl. 52, 1738

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
T cells juxtapose proliferating airway smooth muscle (ASM) and non-organized airway contractile elements (NOACE)
Source: Annual Congress 2009 - Airways remodelling
Year: 2009


α-4 integrin blockade modulates airway smooth muscle (ASM) growth induced by activated, antigen-specific CD4+T cells
Source: Annual Congress 2009 - Airways remodelling
Year: 2009

Upregulation of airway smooth muscle (ASM) cell apoptosis may limit ASM growth during airway remodeling in experimental asthma
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Human airway smooth muscle cell and mast cell interaction is mediated via CD44 and CD51 in asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 712s
Year: 2005

Caveolin-1 expression in airway smooth muscle cells is related to airway responsiveness magnitude in allergic asthma model
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011

Increased activation of TGF-β by asthmatic airway smooth muscle cells via integrin αVβ5
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Novel airway smooth muscle–mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma
Source: Eur Respir J, 56 (1) 1901458; 10.1183/13993003.01458-2019
Year: 2020



DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Mast cell regulation of airway smooth muscle function in asthma
Source: Eur Respir J 2007; 29: 827-830
Year: 2007


Eosinophils promote airway smooth muscle cells differentiation to the contractile phenotype in asthma
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Role of protein phosphatase 5 (PP5) in mediating corticosteroid insensitivity in airway smooth muscle (ASM) cells in severe asthma
Source: International Congress 2015 – New insights into lung disease pathogenesis
Year: 2015

Eosinophil subtypes’ effect on airway smooth muscle cells differentiation and migration in asthma
Source: Virtual Congress 2020 – Respiratory homeostasis and structural changes in disease
Year: 2020


The extracellular matrix deposited by asthmatic airway smooth muscle cells in a resting state reflects a healthy matrix
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015


Compound A (CpdA) suppressed production of corticosteroid-resistant chemokines via GR-independent mechanisms in airway smooth muscle (ASM) cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013

TGFβ1 induced loss of β-adrenergic response in human bronchial smooth muscle cells (hBSMC) is dependent on TGFβ-RI kinase activity: potential therapeutic application in treating airway diseases
Source: Annual Congress 2003 - Mechanisms of lung injury: from bench to bedside
Year: 2003


Regulation of mitochondrial transfer between airway smooth muscle cells: relevance to COPD
Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology
Year: 2019



Eosinophils promote airway smooth muscle cells contractility and a-actin gene expression in asthma
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

MNK-1 inhibition reduces proliferation and CXCL10 in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Intercellular communication between epithelial and smooth muscle cells of airways in mouse lung slices
Source: Annual Congress 2006 - Airway epithelial cells in inflammation
Year: 2006