The effects of multiple dosing of ketoconazole on the pharmacokinetics of a single dose ambrisentan

D. Richards, G. Walker, A. Mandagere, M. Magee, L. Henderson, S. Harris (Harlow, Essex, United Kingdom; Westminster, CO, Philadelphia, Miami, United States Of America)

Source: Annual Congress 2008 - Pulmonary hypertension II
Session: Pulmonary hypertension II
Session type: Thematic Poster Session
Number: 1023
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Richards, G. Walker, A. Mandagere, M. Magee, L. Henderson, S. Harris (Harlow, Essex, United Kingdom; Westminster, CO, Philadelphia, Miami, United States Of America). The effects of multiple dosing of ketoconazole on the pharmacokinetics of a single dose ambrisentan. Eur Respir J 2008; 32: Suppl. 52, 1023

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Safety, tolerability, pharmacokinetics and pharmacodynamics after repeated once or twice daily RVT-1201, a TPH inhibitor for treatment of PAH
Source: International Congress 2019 – Pulmonary hypertension: clinical
Year: 2019


Differences between pharmacokinetics of ciclesonide-active principle and budesonide following repeated dose inhalations
Source: Eur Respir J 2003; 22: Suppl. 45, 33s
Year: 2003

Effects of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2009 - New bronchodilators
Year: 2009


Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

Single therapeutic and supratherapeutic doses of indacaterol have little effect on systemic safety variables in patients with asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 350s
Year: 2007

Effects of steady-state female hormones on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011


Safety and pharmacokinetics of nintedanib plus sildenafil in the INSTAGE trial
Source: International Congress 2019 – Treatment and prognosis of idiopathic interstitial pneumonia
Year: 2019


Pharmacokinetic characteristics of roflumilast administered in gradually increasing doses of 500μg to 1000μg are dose-linear in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 108s
Year: 2002

Once-daily administration of indacaterol does not induce tachyphylaxis in vivo
Source: Eur Respir J 2005; 26: Suppl. 49, 216s
Year: 2005

Roflumilast and sildenafil in healthy male volunteers: Single-dose pharmacokinetic interactions, safety and tolerability
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics II
Year: 2010

No relevant drug-drug interaction between inhaled NVA237 and oral cimetidine
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012


Pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects after a single, oral dose of 500µg roflumilast in the morning versus evening
Source: Eur Respir J 2003; 22: Suppl. 45, 102s
Year: 2003

Dose escalation study in healthy male subjects to investigate safety, tolerability and systemic exposure of orally inhaled single-doses of AP301
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Effect of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Eur Respir J 2006; 28: Suppl. 50, 435s
Year: 2006

Safety, tolerability and pharmacokinetics (PK) of repeated doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in healthy adults
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Interrelationship of pharmacokinetics/pharmacodynamics: antibiotic dosing for the future
Source: ISSN=1025-448x, ISBN=1-904097-32-4, page=1
Year: 2004

Safety and tolerability of the novel very long acting β2-agonist Carmoterol given as a 2μg qd dose; 8 days comparison with formoterol and placebo in patients with persistent asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 665s
Year: 2006

No relevant pharmacokinetic drug–drug interaction between nintedanib and pirfenidone
Source: Eur Respir J, 53 (1) 1801060; 10.1183/13993003.01060-2018
Year: 2019



Efficacy of diltiazem administration on the respiratory adverse effects of enalapril
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002